Mutagenicity assessment

Villalobos-Pietrini, R., S. Blanco, and S. Gomez-Arroyo, Mutagenicity Assessment of Airborne Particles in Mexico City, Atmos. Environ., 29, 517-524 (1995). 

Figure 9-1 is a flow chart for a mutagen assessment system the suggested decision function for short-term tests is shown in Table 9-2. 

Our recommended mutagen assessment program has five levels (outlined in Figure 9-1)s... 

The success of a mutagen assessment program depends strongly on the efficacy of the screening system, for most of the decisions regarding individual chemicals must be made on the basis of short-term screening tests. The criteria for choosing test systems are discussed in Chapter 6. On the basis of these criteria, the Committee has selected a set of tests, listed as "principal shortterm tests" in Table 9-1. Confirmatory rodent tests and supplementary tests are also listed. 

An Overview of the Mutagen Assessment Program 203 Screening Systems 206... 

To increase the throughput a Miniscreen assay platform has been developed. In principle, the Miniscreen is a scaled down version of the standard AMES assay.11 Since the assay is performed in multiwell plates, only 20 mg of test article is needed. However, Miniscreen does not eliminate the serial dilution steps and is not suitable for automation. In addition, it is also rather difficult to obtain quantitative data for mutagenicity assessment. 

Degradation hydrolysis half-life, atmospheric degradation and biodegradation. Ecotoxicity BCF, aquatic toxicity, mammalian toxicity, phytotoxicity and genetic/mutagenic assessment. 

A. Takahashi and H. Ono, Mutagenicity assessment in 44 epoxy resin hardeners in Salmonella typhimurium tester strains, Chem. Express, 1993, 8, 785 788. 

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