Muscle glycogen synthesis

Bergstrom, J. Hultman, E. (1966). Muscle glycogen synthesis after exercise An enhancing factor localized to the muscle cells in man. Nature 210, 309-310. 

Hultman, E. Bergstrom, J. (1967). Muscle glycogen synthesis in relation to diet studied in normal subjects. Acta Med. Scand. 182, 109-117. 

Increased muscle glycogen synthesis, increased Creatine Phosphate (CP) synthesis. 

Semiz, S. and J.H. McNeill. 2002. Oral treatment with vanadium of Zucker fatty rats activates muscle glycogen synthesis and insulin-stimulated protein phosphatase-1 activity. Mol. Cell. Biochem. 236 123-131. 

Blom, P. C., Hostmark, A. T, Vaage, O., Kardel, K. R., and Maehlum, S. (1987). Effect of different post-exercise sugar diets on the rate of muscle glycogen synthesis. Med. Scj. Sports Exercise 19, 491—496. 

G. W. Cline, K. F. Petersen, M. Krssak, et al. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. New England Journal of Medicine 341, 240 (1999). 

Mechanism of Stimulation of Mammalian Skeletal Muscle Glycogen Synthesis... 

Glycogen is stored in the liver and skeletal muscle. Glycogen synthesis and degradation in the liver are carefully regulated. As we will see in Section 21.7, these two processes are intimately involved in keeping blood glucose levels constant. 

Laurent D, Peterson KF, Russell RR, et al. Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans. Am J Physiol 1998 274 E130-E138. 

Ivy, J.L., Katz, A.L., Cutler, C.L., Sherman, W.M., and Coyle, E.F., Muscle glycogen synthesis after exercise effect of time of carbohydrate ingestion, J Appl Physiol, 64, 1480, 1988. 

Jentjens, R.L., Van Loon, L.J., Mann, C.H., Wagenmakers, A.J., and Jeukendrup, A.E., Addition of protein and amino acids to carbohydrates does not enhance postexercise muscle glycogen synthesis, J Appl Physiol, 91, 839, 2001. 

Nevertheless, this possibility remains attractive to consumers, and there is some strong recent evidence that carbohydrates consumed together with protein hydrolysates with added leucine and phenylalanine promote higher insulin secretion than can be achieved with carbohydrate intake alone. The potential advantages of this effect are that it may (1) further promote muscle glucose uptake and stimulate muscle glycogen synthesis, and so both increase the stores of this important fuel prior to exercise and enhance its restoration in the recovery phase after exercise, and (2) stimulate muscle amino acid uptake and protein synthesis during recovery from... 

Muscle Most human rQ MRS studies in muscle have concentrated on the study of glycogen synthesis and its role in NIDDM, glycogen storage diseases and muscle myopathies. Studies of insulin action on muscle glycogen synthesis have shown that there appears to be an impairment of muscle s ability to either take up glucose or assimilate it as glycogen in NIDDM. 

---