Murry Reaction

The degree of polymerization was determined by H-NMR-spectroscopy and MALDI TOP mass spectrometry. Results of H-NMR-spectroscopic investigations prove the defect-free structure and dW-trans configuration. In contrary to the product obtained by Me Murry reaction [19] or by sulfonium precursor route [20] there is no sign for any cis bonding (Figure 3, at the top, marked regions). 

Another series of COX-2 inhibitors was described by Hu et al., and the key step in this reaction is the construction of the indole skeleton by the Mc-Murry coupling reaction [77]. The chemistry described in this paper is shown... 

Scheme 9.15 Imino-Stetter reaction, as reported by Murry, Frantz and colleagues.

Evans DA, Barnes DM, Johnson JS, Lectka T, von Matt P, Miller SJ, Murry JA, Norcross RD, Shaughnessy EA, Campos KR (1999) Bis(oxazoline) and bis(oxazolinyl)pyridine copper complexes as enantioselective Diels-Alder catalysts reaction scope and synthetic applications. J Am Chem Soc 121 7582-7594... 

This reaction is related to the Fukuyama Indole Synthesis, both give 2,3-disubstituted indole derivatives. In addition, this reaction is very closely related to Me Murry Coupling in mechanism. 

The first example of an aldehyde-imine cross-benzoin reaction catalyzed by thiazolylidene carbenes was reported by Murry, Frantz, and co-workers, using arylsulfonylamides as imine precursors. Later, Miller and co-workers disclosed an asymmetric variant of this work by implementing their peptide-derived thiazolium salt as a precatalyst to deliver aryl aldehyde... 

Interestingly, Murry et al. [34] successfully applied acylimines 23 as a suitable coupling partner for crossed coupling condensation, giving a number of a-ketoamides 24 in good yields. The reaction is tolerable for both electron-deficient and electron-rich aldehydes (Scheme 7.16). Mattson and Scheldt [35] found that thioazolium carbene... 

Transition state proposed for enantioselective Diels-Alder reactions catalyzed by a copper-bisoxazoline complex. The orientation of the diene and acrylate in this transition state resembles that in the transition state for an uncatalyzed [4+2] cycloaddition. Adapted from Evans, D. A. Barnes, D. M. Johnson, J. S. Leckta, T von Matt, R Miller, S. J. Murry, J. A. Norcross, R. D. Shaughnessy, E. A. Campos, K. R. J. Am. Chem. Soc. 1999,121,7582. 

Scheme 9.50. A representation of the reaction (in the direction shown by the arrow) between dihexafluoroantimonate [2 (SbFe) ] (5, 5 )-diphenyl[bis(oxazolinyl)pyridine]Cu(II) with benzyloxyacetaldehyde (2-benzyloxyethanal [CeHsCH20CH2CH0]) (after Evans, D. A. Kozlowski, M. C. Murry, J. A. Burgey, C. S. Campos, K. R. Connell, B. T. Staples, R. J. 7. Am. Chem. Soc., 1999,121, 669).

The topogranulator is used extensively to make effervescent products by liquid addition under vacuum or by the Murry fusion method (6). Murry s method uses liberated moisture from the acid in the mix (i.e., hydrous citric acid) to start the acid-base reaction, which generates more water. Thus, granulating of the sodium bicarbonate-citric acid mixture can be accomplished. The water produced must be removed quickly to reproducibly stop the reaction. The topogranultor, because of its ability to compress the particles into the binding moisture, makes a larger, denser... 

Smitrovich JH, Boice GN, Qu C, DiMichele L, Nelson TD, Huffman MA, Murry J, McNamara J, Reider PJ. Pseudo-ephedrine as a chiral auxiliary for asymmetric Michael reactions synthesis of 3-aryl-8-lactones. Org. Lett. 2002 4 1%3-1966. 

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