Murry coupling

Another series of COX-2 inhibitors was described by Hu et al., and the key step in this reaction is the construction of the indole skeleton by the Mc-Murry coupling reaction [77]. The chemistry described in this paper is shown... 

This reaction is related to the Fukuyama Indole Synthesis, both give 2,3-disubstituted indole derivatives. In addition, this reaction is very closely related to Me Murry Coupling in mechanism. 

Reinecke H, MacDonald GH, Hauschka SD, Murry CE. Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair. J Cell Biol 2000 149(3) 73 I -740. 

In the case of nonlinear polarizability coupling, the ratio of the cascaded to direct fifth-order response can be expressed in terms of the ratio of the first and second derivative of the polarizability [Equation (32)]. Using instantaneous normal mode simulations, Murry et al. (40) have calculated the relative ratios of a 11 and at2> for 5000 intermolecular modes in CS2. Although their results show this ratio to be somewhat randomly... 

Murry IA, Frantz DE, Soheili A, Tillyer R, Grabowski EJI, Reider PI (2001) Synthesis of alpha-amido ketones via organic catalysis thiazolium-cata-lyzed cross-coupling of aldehydes with acylimines. I Am Chem Soc 123 9696-9697... 

Murry, J. A., Frantz, D. E., Soheili, A., Tillyer, R., Grabowski, E. J. J., Reider, P. J. Synthesis of -Amido Ketones via Organic Catalysis Thiazolium-Catalyzed Cross-Coupling of Aldehydes with Acylimines. J. Am. Chem. Soc. 2001, 123, 9696-9697. 

Interestingly, Murry et al. [34] successfully applied acylimines 23 as a suitable coupling partner for crossed coupling condensation, giving a number of a-ketoamides 24 in good yields. The reaction is tolerable for both electron-deficient and electron-rich aldehydes (Scheme 7.16). Mattson and Scheldt [35] found that thioazolium carbene... 

Soheili, A., Albaneze-WaUcer, J., Murry, J. A., Dormer, P. G., and Hughes, D. L. (2003). Efficient and general protocol for the copper-free Sonogashira coupling of aryl bromides at room temperature. Org. Lett., 5, 4191 194. 

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