Murine Plus

Proprietary Names. Murine Plus Tyzine Visine Yxin. 

TETRAHYDROZOLINE HYDROCHLORIDE (Collyrium Fresh, Murine Plus, Ocu-Drop, Soothe, Tyzine Pediatric, Visine)... 

Hydroxyamphetamine (paredrine) Naphazoline (ak-con, albalon, CLEAR EYES, NAPHCON, VASOCLEAR, vasocon regular, Others) Tetrahydrozoline (collyrium fresh, murine PLUS, VISINE MOISTURIZING, others)... 

Lejon et al., 2001 (71) Projections to latent structures (PLS) 12 Lactoferricin from bovine (LFB) Lactoferricin from murine (LFM), plus 18 derivatives of LFM that varied at up to 4 positions (same data as Strom et al., 2001) Single training set 20 Good correlation visible in plot nd... 

Two other agents show promise in treatment of ocular toxoplasmosis. Atovaquone, primarily used for mild to moderate episodes of Pneumocystis carinii pneumonia, has been effective in small series of patients with toxoplasmosis. It appears to have activity against both tachy-zoites and tissue cysts. More recent studies on atovaquone in toxoplasmosis are limited to murine models, and no further reports on this drug therapy in humans have been published. Azithromycin, a macrolide antibiotic, is efficacious against T. gondii and can also kill tissue cysts. A randomized study of 46 patients compared the combinations of azithromycin plus pyrimethamine versus pyrimethamine plus sulfadiazine in treatment of ocular toxoplasmosis efficacy was similar, but the azithromycin/ pyrimethamine regimen caused less adverse effects. 

Fig. 1. Time course of cell death parameters in tumor necrosis factor (TNF)-induced apoptosis. Human hepatoma cells (HepG2) were incubated in the presence of 400 nM actinomycin D plus 1.6 ng/ml recombinant human TNF (rhTNF)-a. MTT-dye reduction (parameter of mitochondrial function), lactate dehydrogenase (LDH) release (parameter for cell membrane rupture), and DNA fragmentation (parameter associated with typically apoptotic nuclear changes) were determined over a time period of 24 h. As is characteristic of apoptotic cell death, DNA fragmentation always preceded the other death parameters. Similar findings have been obtained in primary hepatocyte cultures and murine livers...

Immunomodulatory, Immunosupressant. Humanized IgGl Mab that binds to the human IL-2R (anti-CD25). Composite of 90% human (IgGl constant plus variable framework regions of the Eu myeloma Ab) and 10% murine Ab (CDR) sequences. 

WT plus local instillation of s-Dectin 1-fusion protein (with murine IgCI Fc or mutant human IgCI Fc fragment) A. fumigatus Conidia Caudal oropharynx Increased (lung fungal burden and broncho-alveolar fluid cell infiltrate) 12... 

Nitric oxide synthase (EC 1.14.13.39) induction by interferon-y or interferon-y plus hpopolysaccha-ride in BNL CL.2 murine embryonic hver cells was potentiated by ionising radiation (Yoo et al. 2000). H2O2 formed by y-radiation might make the cells responsive for interferon-y or interferon-y plus hpopolysaccharide, as catalase (EC 1.11.1.6) blocked H2O2 formation and NO production. 

Resuspend the cells at 1 x 10 cells/ml in RPMI with 20% PCS plus HAT and 10 ji.m ouabain and dispense 0.1 ml to the wells of the 96-well plate which either cmitain murine macrophages or condilicmed medium. 

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