Murine leukemic lymphoblasts

The present study was undertaken to obtain more information on the uptake and intracellular metabolism of guanosine in murine leukemic lymphoblast (L5178Y). 

Murine leukemic lymphoblasts (L5178Y) were harvested from BDFi hybrid mice (C57BL/6 9X DBA2 <5 ) 10 days after i.p. tumor inoculation of 2 x 10 cells. 

Many of the rifaldehyde derivatives have also been screened for inhibition of the RNA-directed DNA polymerases (reverse transcriptases) of murine sarcoma virus (MSV) and Rauscher murine leukemia virus (RLV) and the purified DNA polymerases from human normal and leukemic lymphoblasts (40,163). Surprisingly perhaps, the best compounds shown in Fig. 19 (48, 49, rifampicin) were inactive. Further testing of derivatives of rifaldehyde indicated tl at a longer, bulkier side chain is needed at C-25 for inhibition of viral polymerases. 

Yang, S. S., F. M. Herrera, R. G. Smith, M. S. Reitz, G. Lancini, R. Ting, and R. C. Gallo Rifamycin Antibiotics Inhibitors of Rauscher Murine Leukemia Virus Reverse Transcriptase and of Purified DNA Polymerases from Human Normal and Leukemic Lymphoblasts. J. Nat. Cancer Inst. 49, 7 (1972). 

Tmjillo J, Aheam MJ, Pienta RJ, Gott C, Sinkovics JG. Immunocompetence of leukemic murine lymphoblasts ultrastmcture, vims and globulin production. Cancer Res. 1970 30 540-5. 

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