Apoptosis multiple sclerosis

The class III cytokine receptor family includes two TNE receptors, the low affinity NGE receptor and 7-ceU surface recognition sites that appear to play a role in proliferation, apoptosis, and immunodeficiency. TNE-a (- 17, 000 protein) is produced by astrocytes and microglia and can induce fever, induce slow-wave sleep, reduce feeding, stimulate prostaglandin synthesis, stimulate corticotrophin-releasing factor and prolactin secretion, and reduce thyroid hormone secretion. TNE-a stimulates IL-1 release, is cytotoxic to oligodendrocytes, and reduces myelination this has been impHcated in multiple sclerosis and encephalomyelitis. Astrocyte TNE-a receptors mediate effects on IL-6 expression and augment astrocytic expression of MHC in response to other stimulants such as lEN-y. 

Apoptosis Induction as a Novel Therapeutic Approach for Multiple Sclerosis 469... 

Apoptosis has been implicated in delayed neuronal death associated with many neurodegenerative disorders such as Parkinson s disease, stroke, Huntington s disease, traumatic head injury, Alzheimer s disease, motor neuron degeneration, spinal cord injury, and multiple sclerosis. Since an extensive description of the role of apoptosis in each of these disorders is beyond the scope of the present text, we shall focus on anti-apoptotic strategies for stroke, Parkinson s disease, and multiple sclerosis. 

T-cells are involved in various inflammatory pathologies such as asthma, multiple sclerosis, and human idiopathic polymyositis. The modification of these cells may thus be an important mechanism to help avoid the damage caused by these afflictions. In the natural disease course of multiple sclerosis, for example, apoptosis contributes to the elimination of T-cells from the inflamed central nervous system. Using corticoids to induce apoptosis could contribute to the down-regulation of... 

Biological Applications Detecting abnormal gametes, apoptosis, human papilloma virus (HPV), single nucleotide polymorphism (SNP), ° mitochondrial membrane potential change, polynucleotides, pro-terns, peptides nucleic acid amplification nucleic acid quantification nucleic acid sequencing treating of cancer, Alzheimers disease, multiple sclerosis,... 

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