Cooperating ligand

Usually non-cooperative and non-Unear binding isotherms were observed in alkaloid-B-DNA complexation and the data were fitted to a theoretical curve drawn according to the excluded site model [126] developed by McGhee and von Hippel [127] for a non-Unear non-cooperative ligand binding system using the following equation ... 

Khvostichenko D, Yang Q, Boulatov R. 2007. Simple heme dimers with strongly cooperative ligand binding. Angew Chem Int Ed 46 8368. 

Linked-function mechanisms for cooperative binding interaction of metabolites and/or drugs, based on the presence of two or more different conformational states of the protein or receptor. See Adair Equation Cooperative Ligand Binding Hemoglobin Hill Equation Plot Koshland-Nemethy-Filmer Model Monod-Wyman-Changeux Model Negative Cooperativity Positive Cooperativity... 

ADAIR EQUATION COOPERATIVE LIGAND BINDING HILL EQUATION PLOT KOSHLAND-NEMETHY-EILMER MODEL MONOD-WYMAN-CHANCEUX MODEL NEGATIVE COOPERATIVITY POSITIVE COOPERATIVITY HEMOGLOBIN ALLOTOPIC EFFECT Allowed electronic transitions,... 

COOPERATIVE LIGAND BINDING EQUILIBRIUM CQNSTANT EQUILIBRIUM DIALYSIS HUMMEL-DREYER METHQD LINKED EUNCTIQN THEQRY KLQTZ PLQT... 

NEGATIVE COOPERATIVITY LIGAND BINDING COOPERATIVITY Ligand occupancy,... 

HALF-REACTIONS NEGATIVE COOPERATIVITY LIGAND BINDING... 

LIGAND BINDING COOPERATIVE LIGAND BINDING SATURATION KINETICS Saturation ratio,... 

Cooperative binding of oxygen by hemoglobin was first analyzed by Archibald Hill in 1910. From this work came a general approach to the study of cooperative ligand binding to multisubunit proteins. 

FIGURE 5-15 Two general models for the interconversion of inactive and active forms of cooperative ligand-binding proteins. Although the... 

Dose-effect curves may take different shapes, due to cooperative ligand binding. ... 

There still remains the question, which is unanswered by either the TT-bonding hypothesis or by the concept of metal polarizing power, as to why cobalt(III) and manganese(I) experience a cooperative ligand effect, whereas there is no evidence as yet for such an effect with chromium in various oxidation states [any Cr(III)—SCN compounds are purely kinetic in origin and thermodynamically unstable with respect to Cr(III)— NCS] with iron(II) or iron(III), cobalt(II), or nickel-(II), even though the stereochemistries of these last two elements may be drastically modified by ligational effects (see Tables XXIX and XXXI). 

Summary of Cooperative Ligand and Solvent Effects ON Thiocyanate Coordination... 

Williams, D. H., Davies, N. L., Zerella, R., Bardsley, B. Noncovalent interactions defining cooperativity. Ligand binding aided by reduced dynamic behavior of receptors. Binding of bacterial cell wall analogues to ristocetin A. J. Am. Chem. Soc. 2004,126, 2042—2049. 

Hyde, J. Braisted, A. Randal, M. Arkin, M. Discovery and Characterization of Cooperative Ligand Binding in the Adaptive Region of Interleukin-2, Biochemistry 42, 6475-6483 (2003). 

Strategy III. Cooperative ligand-centered reactivity based on redox active ligands... 

Hyde J, Braisted AC, Randal M, Arkin MR (2003) Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2. Biochemistry 42 6475-6483... 

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