Multiple automated robotic synthesizer

Krchnak, V., Cabel, D., and Lebl, M. (1996) MARS Multiple automated robotic synthesizer for continuous flow of peptides. Peptide Res. 9, 45-49. 

For continuous peptide synthesis, a multiple automated robotic synthesizer (MARS) was designed and constructed by Selectide Corporation. Its main feature was a timing procedure for handling multiple synthetic tasks that eliminated any unnecessary respite time and kept the robot arm continuously in operation. Polypropylene syringes equipped at the bottom with polypropylene frits served as physically independent reaction vessels. All operations were performed by the robotic arm, which was equipped with a specially designed gripper to hold a syringe and to aspirate and dispense liquid. Typically, the MARS... 

Zuckermann, R. N., Siani, M. A., and BanvUle, S. C. (1992) Control of the zymate robot with an external computer Construction of a multiple peptide synthesizer. Lab. Robotics Automation 4, 183-192. 

In 1992, ACT replaced the Model 350 with the Model 396 Multiple Biomolecular Synthesizer. This instrument possesses two robotic arms, a variable speed orbital mixer, nitrogen assisted bottom filtration, a built-in ventilation system, protocols for both Fmoc and Boc synthesis and fully automated on-board cleavage for the Fmoc syntheses. It has reactor blocks of 8, 16, 40, and 96 wells for the synthesis of peptides from 5 pmol to 1 mmol. The Model 396 MBS also has a heater/cooler option for applications in solid-phase organic synthesis. 

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