Mucosal hyperplasia

Allen JR, Norback DH. 1973. Polychlorinated biphenyl- and triphenyl-induced gastric mucosal hyperplasia in primates. Science 179 498-499. 

Allen, J., and Norback, D. 1973. Science 179. 498 PCB and PCT-induced gastric mucosal hyperplasia in primates. 

In this model the secondary bile acid sodium deoxycholate appears to be neither tropic nor co-carcinogenic to hypoplastic defunc-tioned colon. The previously cited experiment showing that bile and pancreatic juice could stimulate adaptive mucosal hyperplasia and carcinogenesis after surgical diversion involved distal gut remaining in continuity with the faecal stream[29]. Thus any effect of bile acids in promoting colorectal neoplasia or in maintaining mucosal cell turnover is likely to depend in part on other luminal factors. 

Does oxyntic mucosal hyperplasia result in hypersecretion of acid after withdrawal of treatment ... 

Muc2 and Muc3, and mucin mRNA are coordinately upregulated in response to T. spiralis infection and may form the basis of an innate mucosal response independent of specific IFN-y, TNF and IL-4 cytokines. Importandy, this study also demonstrated that goblet cell hyperplasia and upregulated mucin secretion are not essential components of the protective immune response to GI helminths. 

In chronic studies, male and female rats and mice tolerated up to 2.5 ppm chlorine gas for 6 h/day, 5 days/week for 2 years (CUT, 1993 Wolf et al, 1995). Concentration-dependent lesions confined to the nasal passages were observed in all animals. These lesions were most severe in the anterior nasal cavity and included respiratory and olfactory epithelial degeneration, septal fenestration, mucosal inflammation, respiratory epithelial hyperplasia, squamous metaplasia and goblet cell hypertrophy and hyperplasia, and secretory metaplasia of the transitional epithelium of the lateral meatus. Body weight was depressed compared to controls but no early deaths occurred. A similar lack of lower respiratory tract effects was seen in monkeys exposed to 2.3 ppm chlorine for 6 h/day, 5 days/week, for 1 year (Klonne et al, 1987). At these concentrations, chlorine is effectively scrubbed in the anterior nasal passages as indicated by the absence of lesions in the lung. 

Acids are corrosive to skin and mucosal surfaces. Repetitive ingestion of acids may induce mucosal forestomach hyperplasia. 

Repetitive exposure to acrylic acid may induce mucosal forestomach hyperplasia. 

Gingival hyperplasia/hypertrophy Oral mucosal eruption... 

Gingival hyperplasia/hypertrophy (2001) Das SJ +, J Periodontol 72(6), 745 Oral mucositis... 

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