Mucosal addressin cell adhesion molecule-1 MAdCAM

Figure 1 Movement of T lymphocytes from the blood into the lymph nodes, (a) Soluble or endothelial-displayed CCL21 ( ) binds CCR7 ( ). (b) The interaction induces a change in the conformation of the integrin tt4P7 from low affinity (I) to high affinity ( ). (c) The high affinity integrin then binds to mucosal addressin cell adhesion molecule-1, MAdCAM-1 (C), causing cell adhesion, (d) Directed cell migration between endothelial cells results.

Pachynski RK, Wu SW, Gunn MD, Erie DJ. Secondary lymphoid-tissue cytokine stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J Immunol 1998 161 953-956. 

During the generation of functional lymphoid tissue organizers, LT-pR signaling leads to expression of mucosal addressin cell adhesion molecule (MAdCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cell-adhesion molecule 1 (VCAM-1) on endothelial cells, as well as the production of the chemokines CXCL13, CCL19, and CCL21 by stromal cells and HEVs (Carlsen et al., 2005). 

P7 a4 Fibronectin, VCAM, Mucosal addressin cell adhesion molecule (MAdCAM)... 

MAdCAM Mucosal addressin cell adhesion molecule... 

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