Cell adhesion MAdCAM

During the generation of functional lymphoid tissue organizers, LT-pR signaling leads to expression of mucosal addressin cell adhesion molecule (MAdCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular cell-adhesion molecule 1 (VCAM-1) on endothelial cells, as well as the production of the chemokines CXCL13, CCL19, and CCL21 by stromal cells and HEVs (Carlsen et al., 2005). 

Figure 1 Movement of T lymphocytes from the blood into the lymph nodes, (a) Soluble or endothelial-displayed CCL21 ( ) binds CCR7 ( ). (b) The interaction induces a change in the conformation of the integrin tt4P7 from low affinity (I) to high affinity ( ). (c) The high affinity integrin then binds to mucosal addressin cell adhesion molecule-1, MAdCAM-1 (C), causing cell adhesion, (d) Directed cell migration between endothelial cells results.

Pachynski RK, Wu SW, Gunn MD, Erie DJ. Secondary lymphoid-tissue cytokine stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. J Immunol 1998 161 953-956. 

MAdCAM Mucosal addressin cell adhesion molecule... 

P7 a4 Fibronectin, VCAM, Mucosal addressin cell adhesion molecule (MAdCAM)... 

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