Mucin Structural Properties

Mucin Structural Properties 2.2.1 Multi-domain Organization... 

Gu, J. M., Robinson, J. R., and Leung, S. H. Binding of acrylic polymers to mucin/epithelial surfaces Structure-property relationships. Crit. Rev. Ther. Drug Carrier Syst. 1988, 5(1), 21-67. 

Doi M. and See H. Introduction to polymer physics. USA Oxford University Press 1995 Eckhardt A.E., Timpte C.S., Abernethy J.L., Toumadje A., Johnson W.C. and Hill R.L. (1987). Structural properties of porcine submaxillary mucin. J Biol Chem. 262, 11339-11344... 

T. A., Biophysical approaches to salivary mucin structure, conformation, and dynamics, Crit. Rev. Oral Biol. Med. 4, 261-270, 1993 Dodd, S., Place, G.A., Hall, R.L., and Harding, S.E., Hydrodynamic properties... 

Mucins from a wide range of sources show the same basic structural properties a heavily glycosylated basic unit of M, 0.5 X 10, linked by covalent (or other sufficiently long-lived) bonds into linear arrays that are polydisperse with respect to numbers of basic units (discrete polydispersity)... 

D. Carlson, Structures and immunological properties of oligosaccharides isolated from pig submaxillary mucins, J. Biol. Chem., 243 (1968) 616-626. 

Mucin polypeptides comprise thousands of amino acid residues organized into different protein domains with specific structural and/or functional properties (Fig. 2.1) (Perez-Vilar and Hill 1999 Dekker et al. 2002). 

A detailed discussion of the structure and properties of mucus and respiratory mucins is given in Chapter 9 (Section 9.2.4.2). 

It is not the purpose of this article to discuss in detail the gelation properties of these macromolecules, as consideration of this can be found elsewhere (see, for example, Ref. 12). The glycoproteins found in submandibular and submaxillary secretions will also not be considered. Although these substances are also referred to as mucins, they have somewhat different characteristics (namely, a considerably lower proportion of carbohydrate, shorter carbohydrate chains of different structure and composition) and properties (such as a lower viscosity). A study has however shown that they have a greater overall homology with other mucins in terms of assembly and conformation than was perhaps originally presumed. 

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