Mucin, blood group substances from

HMF. See 5-HydroxymethyIfurfural. Hog mucin, blood group substances from, IV, 43, 46... 

King and Morgan obtained a very active blood group substance from the cystic fluids of individuals of group A and were able to show that it was very similar in properties to the substance they obtained from hog mucin. More recently Morgan and Waddell have reported the isolation of the corresponding O material from group 0 cystic fluid. The sub-... 

A constit. of the polysaccharides obt. from eggs of sea urchin, frog spawn, gum tragacanth and marine algae. Also found in glycoproteins obt. from mucins, blood group substances and milk. 

As we know at present, the mucoproteose fraction includes the following materials (1) most of the gastric fucomucins, as well as some of the blood group substances, i.e., most of the neutral polysaccharides of the dissolved mucin fraction linked to their peptide moiety, (2) y-globulin and probably also P-globulin, which pass into the gastric juice from the serum (G16, G42, Hll, H20, H55) and probably account for the presence of mannose in this fraction (Gll), (3) some of the pep-tidic degradation products of serum albumin and visible mucus, which are partly dialyzable (G16, K2), (4) native intrinsic factor, the related primary vitamin Bi2 binder, and tertiary vitamin Bia binder related to the neutral mucosubstances (G14, Ul, U2). 

Gyorgy (G77) demonstrated the presence of a factor required for the growth of L. bifidus in milk (especially human). However, it was also found in other body fluids, including human gastric juice (even from a pernicious anemia patient), and in hog gastric mucin and blood group substances A and B (G77, G78, S36, S37). 

Complex, blood-group-active substances have been employed as inhibitors of hemagglutination.196,693 Osawa and Matsumoto found692 inhibition of both Ulex lectins by human A-, B-, and H-active substances, whereas Lea substance and porcine, submaxillary mucin bound only to Ulex II. Chuba and coworkers693 reported that substances from porcine stomach (A-active), equine stomach (B-active), and baboon stomach (A-, B-, and O-active substances), as well as human A-, B-, and O-active substances, bound equally well to both U. europeus lectins. However, porcine, submaxillary mucin and nonsecretor saliva inhibited only Ulex II activity. 

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