MRI contrast agent

At low temperature, the H NMR spectra for [Ln(DTPA)], where Ln = Pr, Eu and Yb, display 18 signals, which coalesced to 9 signals upon the increase of temperature. The exchange was studied by EXSY spectroscopy [176,177], Ln binding of the three nitrogens of the diethylenetriamine backbone results in chirality of the central nitrogen, the two enantiomers cannot be discriminated [Pg.202]

NMR spectra of Ln complexes of DTPA-bis(amides) showed a large number of resonances, indicative of the presence of various isomers [179,180]. [Pg.204]

For the a-substituted DOTA derivatives, the introduction of the chiral centers of equal configuration to all four acetate arms of the DOTA results in four possible diastereomers (RRRR and SSSS) upon metal binding. However, the occurrence of only two isomers appears to be features of Ln complexes of such DOTA derivatives. Both Yb and Eu complexes of DOTAM (DOTAM = 1,4,7,10-tetrakis(carbamoylmethyl) 1,4,7-tetraazacyclododecane) [Pg.206]

It was elegantly demonstrated that the rate of water exchange at the Ln is dependent on the nature and composition of the isomers of a given complex [188,194], The water exchange rate also depends on the extent of second sphere hydration which is determined by complex hydrophobicity and the nature of [Pg.209]

Gadolinium(ni) chelates as magnetoresonance imaging (MRI) contrast agents 99CRV2293. [Pg.234]

Briicher E (2002) Kinetic Stabilities of GadoUnium(III) Chelates Used as MRI Contrast Agents. 221 103-122... [Pg.231]

Chivers T (2003) Imido Analogues of Phosphorus Oxo and Chalcogenido Anions. 229 143-159 Chow H-F, Leung C-F, Wang G-X, Zhang J (2001) Dendritic Oligoethers. 217 1-50 Clarkson RB (2002) Blood-Pool MRI Contrast Agents Properties and Characterization. 221 201-235... [Pg.232]

Perrier RJ (2001) Direct Conversion of 5,6-Unsaturated Hexopyranosyl Compounds to Functionalized Glycohexanones. 215 277-291 Frey H, Schlenk C (2000) Silicon-Based Dendrimers. 210 69-129 Forster S (2003) Amphiphilic Block Copolymers for Templating Applications. 226 1-28 Frullano L, Rohovec J, Peters JA, Geraldes CFGC (2002) Structures of MRI Contrast Agents in Solution. 221 25-60... [Pg.233]

Jacques V, Desreux JF (2002) New Classes of MRI Contrast Agents. 221 123-164 James TD, Shinkai S (2002) Artificial Receptors as Chemosensors for Carbohydrates. 218 159-200... [Pg.234]

Schwert DD, Davies JA, Richardson N (2002) Non-Gadolinium-Based MRI Contrast Agents. 221 165-200... [Pg.238]

Toth E, Hehn L, Merbach AE (2002) Relaxivity of MRI Contrast Agents. 221 61-101 Tovar GEM, Krauter I, Gruber C (2003) Molecularly Imprinted Polymer Nanospheres as Fully Affinity Receptors. 227 125-144... [Pg.239]

Frullano L, Rohovec J, Peters JA, Geraldes CFGC (2002) Structures of MRI Contrast Agents in Solution. 221 25-60... [Pg.257]

Clarkson RB (2002) Blood-Pool MRI Contrast Agents Properties and Characterization. 221 201-235... [Pg.216]

Gries H (2002) Extracellular MRI Contrast Agents Based on Gadolinium. 221 1-24 Grolle F, see Behrens C (2004) 236 187-204... [Pg.217]

The hydration state of lanthanide(III) chelates can be assessed by different techniques. Luminescence studies are widely used for Eu111 and Tb111 chelates (see Chapter 9.21).17 18 170 NMR chemical shift measurements in solution of lanthanide(III) (most often Dy or Gd) complexes can also give information on q.19 These techniques in the context of MRI contrast agent research have been reviewed in 2001.1... [Pg.847]

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