Morphology nodes

Lymphoreticular Effects—Represent morphological effects involving lymphatic tissues such as the lymph nodes, spleen, and thymus. 

The pathophysiology of HL is defined by the presence of the RS cell in a grouping of lymph nodes. The RS cell is a large cell morphologically with a multinucleated structure with pronounced eosinophilic nucleoli.5 In the affected lymph nodes, the RS cells are contained in a reactive milieu of T lymphocytes, eosinophils, histiocytes, and plasma cells, which makes them difficult to distinguish from these background cells. The natural course of the disease, if left untreated, is less than a 5% probability of surviving 5 years. 

Characterization of the morphology of the lymphocytes, the reactivity of the other cells in the lymph node, and the lymph node architecture is essential in obtaining a diagnosis and predicting disease course. The nodal presentation of NHL is divided into two main categories follicular, corresponding with... 

Jylling AMB, Lindebjerg J, Nielsen L, et al. Immunohistochemistry on frozen section of sentinel lymph nodes in breast cancer with improved morphology and blocking of endogenous peroxidase. Appl. Immunohistochem. Mol. Morphol. 2008 16 482-484. 

Ward, J.M., Uno, H. and Frith, C.H. (1993) Immunohistochemistry and morphology of reactive lesions in lymph nodes and spleen of rats and mice. Toxicologic Pathology, 21, 199—205. 

M26. Mollejo, M., Lloret, E., Menarguez, J., Piris, M. A., and Isaacson, P. G., Lymph node involvement by splenic marginal zone lymphoma Morphological and immunohistochemical features. Am. J. Surg. Pathol. 21, 772-780 (1997). 

V5. van Krieken, J. H., von Schilling, C., Kluin, P. M., and Lennert, K., Splenic marginal zone lymphocytes and related cells in the lymph node A morphologic and immunohistochemical study. Hum, Pathol. 20,320—325 (1989). 

---