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Morphine nalorphine

Much attention continues to be directed towards compounds of this class as a result of their now well-established analgesic properties in man, and the subject has been well reviewed [7, 180, 181]. The discovery that nalorphine was equi-potent with morphine in man, accidently revealed during studies of morphine-nalorphine mixtures [158, 182, 183], led to the clinical evaluation of other narcotic antagonists (both proven and potential) and has culminated in the development of the valuable drug pentazocine. Specific compounds of importance are considered below. [Pg.255]

A hypothesis has been advanced to explain the different pharmacological response to opioid agonists and antagonists in terms of conformational differences about the basic center, as discussed in Chapter 13. However, a study by 13C-nmr of two such pairs (morphine-nalorphine, oxymorphone-naloxone) revealed little difference between agonist and antagonist molecules in either piperidine ring conformation (chairs only) or ratio of N- R axial to equatorial forms (83 17 for morphine, virtually 100% eq JV-R for 14-OH derivatives).035 ... [Pg.430]

Apomorphine (— black), azatadine, benorylate, bisacodyl, buprenorphine, butriptyline, captodiame, chloro-pyrilene, chlorpromazine, clofazimine, codeine, diamorphine, diethylthiambutene, dihydrocodeine, dimeth-indene blue), dimethoxanate, doxorubicin, doxylamine, ethopropazine, ethoxazene, guaiphenesin, guanoxan, hexocyclium methylsulphate, mepyramine, 6-monoacetylmorphine, morphine, nalorphine, nor-morphine, oxprenolol, oxyphenisatin, pecazine, penthienate, perazine, perphenazine, phenoxybenzamine, phenyltoloxamine, pholcodine, pimozide, pipoxolan (-> grey), prochlorperazine, procyclidine, promazine, promethazine, proquamezine, solanidine, thenium, thiopropazate, tricyclamol, trimeprazine, viloxazine... [Pg.140]

A table showing the relative activities of morphine, nalorphine, pentazocine, enkephalins, pethidine, and naloxone is shown in Fig. 12.33. A plus sign indicates the compound is acting as an agonist. A minus sign means it acts as an antagonist. A zero sign means there is no activity or minor activity. [Pg.272]

Morphine Nalorphine Pentazocine Enkephalins Pethidine Naloxone... [Pg.272]

Effect of morphine, nalorphine, naloxone, pentazocine, cyclazocine, and oxotremorine on the synthesis and release of acetylcholine by mouse cerebral cortex slices in vitro Howes, John F. Harris, Louis Selig Dewey, William L. [Pg.152]

Perly, Pappalardo and Grassi [41, 43] have analysed the 600 MHz H-NMR spectra of morphine, nalorphine and oxymorphone hydrochlorides and obtained evidence of molecular conformation from V coupling magnitudes. [Pg.369]

Lurie, I.S. McGuiness, K. The quantitation of heroin and selected basic impur-ties via reversed phase HPLC. II. The analysis of adulterated samples. J.Liq.Chromatogr., 1987, 10, 2189—2204 [also impurities, acetaminophen, acetylcodeine, acetylmorphine, acetylprocaine, aminopyrene, amitriptyline, antipyrene, aspirin, barbital, benztropine, caffeine, cocaine, codeine, diamorphine, diazepam, diphenhydramine, dipyrone, ephedrine, ethylmorphine, lidocaine, meconin, methamphetamine, meth-ap Tilene, methaqualone, monoacetylmorphine, morphine, nalorphine, niacinamide, nicotinamide, noscapine, papaverine, phenacetin, phenmetrazine, phenobarbital, phenolphthalein, procaine, pro-panophenone, propoxyphene, P5rilamine, quinidine, quinine, salic lamide, saUsalicylic acid, secobarbital, strychnine, tetracaine, thebaine, tripelennamine, tropacocaine, vitamin B3, vitamin B5 electrochemical detection]... [Pg.24]

Theodoridis, G. Papadoyannis, I. Vasilikiotis, G. Tsoukali-Papadopoulou, H. Reversed-phase high-performance liquid chromatography-photodiode-array analysis of alkaloid drugs of forensic interest. J.Chromatogr.B, 1995, 668, 253-263 [also amphetamine, bamifylline, caffeine, cocaine, codeine, dia-morphine, ethylmorphine, flufenamic acid, methadone, morphine, nalorphine, norcodeine, papaverine, quinine, scopolamine, strychnine, theobromine, theophylline, tolfenamic acid]... [Pg.176]

Noninterfering acetaminophen, amitriptyline, aspirin, atenolol, camazepam, carbamaze-pine, chlorimipramine, chlorthalidone, clonetzepam, cortisone, desipramine, diazepam, halazepam, hydrochlorothiazide, hydrocortisone, imipramine, lorazepam, maprotiline, meperidine, methylphenobarbital, methylprednisolone, metoclopramide, midazolam, morphine, nalorphine, naloxone, nitrazepam, nortriptyline, oxeizepam, oxprenolol, phenobar-bital, phenji oin, pindolol, prazepam, prednisolone, prednisone, primidone, prochlorperazine, propranolol, salicylic acid, temazepam... [Pg.418]

Persson, K. Lindstrom, B. Spalding, D. Wahlstrom, A. Rane, A. Determination of codeine and its metabolites in human blood plasma and in microsomal incubates by high-performance hquid chromatography with ultraviolet detection. J.Chromatogr., 1989, 491, 473-480 Harris, S.C. Miller, M.A. Wallace, J.E. Determination of codeine and morphine in human plasma by high performance liquid chromatography with serial electrochemical detection. Ann.Clin.Lab.Sci., 1988, 18, 297-305 [also ethylmorphine, morphine, nalorphine electrochemical detection]... [Pg.433]

See other pages where Morphine nalorphine is mentioned: [Pg.343]    [Pg.124]    [Pg.2]    [Pg.86]    [Pg.406]    [Pg.406]    [Pg.411]    [Pg.482]    [Pg.491]    [Pg.201]    [Pg.634]    [Pg.123]    [Pg.364]    [Pg.178]    [Pg.24]    [Pg.228]    [Pg.1047]    [Pg.46]    [Pg.260]    [Pg.24]    [Pg.24]    [Pg.228]    [Pg.1047]   
See also in sourсe #XX -- [ Pg.279 ]



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Nalorphine

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