MOPP

MOPP and other combined chemotherapy including alkylating agents (Suppl. 7 1987)... 

Nitrogen mustard is clinically used for the treatment of lymphomas and some forms of lung cancer. The major indication for mechlorethamine is Hodgkin s disease as a part of the MOPP regimen (mechlorethamine + vincristine (oncovin) + procarbazine + prednisone). The usual dose consists of 6 mg/m2 on days 1 and 8. This drug has pronounced hematological toxicity (myelo-suppression). 

More recently, a German study compared a dose-escalated regimen of BEACOPP (with filgrastim support) with standard-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone, gemcitabine (BEACOPP) and COPP alternating with ABVD (C—cyclophosphamide instead of mechlorethamine for MOPP).18 The escalated BEACOPP was... 

Canellos GP, Anderson JR, Propert KJ, et al. Chemotherapy of advanced Hodgkin s disease with MOPP, ABVD, or MOPP alternating with ABVD. New Engl J Med 1992 327 ... 

MOPP - mission-oriented protective posture, level 4. 

The basic requirements for the CBMS II are to reliably detect and identify with sufficient sensitivity and selectivity both CWA and BWA in point detection and reconnaissance missions, in order to be deployable in wheeled reconnaissance vehicles and be operable by nontechnical personnel wearing, at the extreme, MOPP IV protective gear. Contrary to the usual practice for a military detector system, the CBMS II does not have its own requirements document. Instead, the requirements and specifications for the CBMS II are based on the detector requirements of the host platforms in which it will be deployed. These requirements are described in terms of performance, as opposed to the usual practice of being enumerated in volumes of detailed specifications. As is usual for a complex multiyear program, the requirements changed over the course of the CBMS II program as the requirements for the host platforms evolved. 

MOPP Mission-Oriented Protective Posture, the protective clothing used by members of the U.S. military who engage in nuclear, biological, and chemical warfare. MOPP gear provides a flexible system requiring personnel to wear only that protective clothing and equipment appropriate to the threat level, work rate imposed by the mission, temperature, and humidity. 

Military Oriented Protective Posture (MOPP), 5 834-835 Military specifications, for hydrazines,... 

Jenkin D, Chan H, Freedman J, et al. Hodgkin s disease in children treatment results with MOPP and low-dose, extended-field irradiation. Cancer Treat Rep 1982 66 949-959. 

The chemotherapy of advanced Hodgkin s disease is one of the best examples of successful combination chemotherapy. Combination therapy with the MOPP regimen (mechlorethamine, Oncovin [vincristine sulfate], procarbazine, prednisone), alternating with ABVD (Adriamycin [doxorubicin hydrochloride], bleomycin, vinblastine, dacarbazine), has resulted in cure rates of 50 to 60%. 

The major indication for mechlorethamine is Hodgkin s disease the drug is given in the MOPP regimen (mechlorethamine, vincristine, procarbazine, prednisone see Chapter 55). Other less reactive nitrogen mustards are now preferred for the treatment of non-Hodgkin s lymphomas, leukemias, and various solid tumors. 

Chemotherapy, eombined, including alkylating agents (see MOPP and other eombined ehemotherapy ineluding alkylating agents) Chloral... 

MOPP Mechlorethamine, vincristine (Oncovin), procarbazine, prednisone MTX Methotrexate... 

This is present in mechlorethamine (Mustargen), which is used in patients with Hodgkin s disease and other lymphomas, usually in combination with other drugs, such as in MOPP therapy (mechlorethamine, Oncovin [vincristine], procarbazine, and prednisone). It may cause bone marrow depression. 

Hodgkin s disease Mechlorethamine, Oncovin (vincristine), procarbazine, and prednisone (MOPP). 

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