Monoclonal antibody trends

Chiswell DJ, McCafferty I, Phage antibodies Will new coliclonal antibodies replace monoclonal antibodies Trends Biotechnol., 10 80-84, 1992. 

Reichert, J.M., Therapeutic monoclonal antibodies trends in development and approval in the US. Curr Opin Mol Ther 2002, 4(2), 110-118. 

Development trends for monoclonal antibody cancer therapeutics, Nature Reviews Drug Discovery 6 340-356... 

Van der Laan JW, Pentsuk N (2011) ICH S6 regulatory reproduction studies to support the use of monoclonal antibodies. In Weinbauer GF, Vogel F (eds) Future trends in primate toxicology and biotechnology. Waxmann, Muenster, pp 143-162... 

Gelboin HV, Krausz KW, Gonzalez FJ, et al. Inhibitory monoclonal antibodies to human cytochrome P450 enzymes a new avenue for drug discovery. Trends Pharmacol Sci 1999 20 432-438. 

Lee, H.A. and Morgan, M.R.A. 1993. Food immunoassay Applications of polyclonal, monoclonal and recombinant antibodies. Trends Food Sci Technol 4 129-132. 

Shire, S. J. Gombotz, W. Bechtold-Peters, K. Andya, J., Eds. Current Trends in Monoclonal Antibody Development and Manufacturing, Springer New York New York (NY), 2010. 

Reisner Y, Dagan S. The Trimera mouse generating human monoclonal antibodies and an animal model for human diseases. Trends Bio-technol. 1998 16 242-246. 

Stein, K.E., Overcoming obstacles to monoclonal antibody product development and approval. Trends Biotechnol 1991, 15(3), 88-90. 

Anytime the term process chemist is used, it usually relates to the development of a small synthetic molecule. However, there has been a growth explosion in the development of macromolecules as of late. These may include proteins, small molecules attached to proteins, pegylated proteins, DNA and RNA fragments, oligonucleotides, monoclonal antibodies, and even personalized medicines in vaccines being made from a specific patient to treat the same patient. As this is a growing trend within the pharmaceutical industry, the term process chemist should include development chemists who are involved in all of the above-mentioned areas. A major difference between these areas and the development of small molecules is that the process to manufacture these complex products usually defines the product versus the other way around for small molecules, where the product defines the process. 

Birch, J. R., and Lennox, E. S., eds. (1994) Mcmoclcmal Antibodies, WUey-liss, New York EzzeU, C. (2001) Sci. Am. 285(Oct), 36-41 s Greaves, M. F., ed. (1984) Monoclonal Antibodies of Receptors Probes for Receptor Structure, Chapman HaU, London Tzartos, S. J. (1984) Trends Biochem. Sci. 9, 63-67 Harlow, E., and Lane, D. (1999) Using Antibodies A Laboratory Manual, Gold Spring Harbor Lab. Press, Cold Spring Harbor, New York... 

Reichert, J.M. and Valge-Archer, V.E. (2007) Development trends for monoclonal antibody cancer therapeutics. Nature Reviews. Drug Discovery, 6, 349-356. 

Lubiniecld, A., VoUdn, D.B., Federici, M., et al. (2010) Comparability assessments of process and product changes made dining development of two different monoclonal antibodies. Biologicals, 39 (1), 9-22. Doblhoflf-Dier, O., BUem, R. (1999) Quality control and assurance from the development to the production of biopharmaceuticals. Trends Biotechnol, 17 (7), 266-270. 

Figure 9.12 The MALDI mass spectrum of a mouse monoclonal antibody. The matrix used was nicotinic acid the laser radiation used was 266 nm. (Reprinted from Trends Anal. Chem., 9, Karas, M. and Bahr, U., 323, Copyright 1990, with permission from Elsevier.)...

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