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Adrenergic neurones, blockade

STRUCTURE-ACTIVITY RELATIONSHIPS FOR ADRENERGIC NEURONE BLOCKADE 139... [Pg.124]

Relationship between noradrenaline depletion and adrenergic neurone blockade 200 ADDENDUM 203... [Pg.124]

The guanidine function in compounds such as guanethidine is essentially completely protonated at physiological pH, and adrenergic neurone blockade is presumably caused by interactions of the cationic species at hypothetical... [Pg.148]

This apparent enhancement of adrenergic neurone blockade by ortho substitution is somewhat analogous to the increase in blocking activity resulting from ortho substitution in phenoxyalkylguanidines. [Pg.156]

That adrenergic neurone blockade was caused by inhibition of the release of the neurotransmitter substances during nerve stimulation, was shown by... [Pg.160]

The dimethylguanidine (LXVII, R = R = Me) causes vasodilatation but lowers blood pressure as a consequence of adrenergic neurone blockade [278]. Apparently, the related imidazoline (LXVIII) is not an adrenergic neurone blocking agent but a hypotensive, which acts by vasodilatation and blockade of a-receptors [279]. [Pg.168]

There is no correlation between the monoamine oxidase inhibitory activity of guanidine derivatives and their ability to cause adrenergic neurone blockade or depletion of noradrenaline [259]. The contribution made by monoamine oxidase inhibition to the antihypertensive properties of guanidines remains to be... [Pg.191]

Another suggested explanation for guanethidine-induced depletion is that guanethidine liberates noradrenaline from its stores by persistent activation of the normal process of physiological release [323]. This hypothesis has important consequences in connection with the mechanism by which guanethidine produces adrenergic neurone blockade, and will be discussed below. [Pg.196]

See other pages where Adrenergic neurones, blockade is mentioned: [Pg.64]    [Pg.124]    [Pg.126]    [Pg.140]    [Pg.140]    [Pg.140]    [Pg.146]    [Pg.150]    [Pg.150]    [Pg.152]    [Pg.154]    [Pg.154]    [Pg.159]    [Pg.168]    [Pg.170]    [Pg.171]    [Pg.172]    [Pg.172]    [Pg.174]    [Pg.174]    [Pg.176]    [Pg.177]    [Pg.185]    [Pg.186]    [Pg.186]    [Pg.187]    [Pg.188]    [Pg.190]    [Pg.191]    [Pg.194]    [Pg.196]    [Pg.197]    [Pg.197]    [Pg.198]    [Pg.198]    [Pg.198]    [Pg.199]    [Pg.199]    [Pg.201]    [Pg.201]    [Pg.203]   
See also in sourсe #XX -- [ Pg.138 , Pg.171 , Pg.174 , Pg.202 , Pg.203 ]



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