Mono-oxygenase model systems

Iley, J., L. Constantino, F. Norberto, and E. Rosa (1990). Oxidation of the methyl groups of N,N-dimethylbenzamides by a cytochrome P450 mono-oxygenase model system. Tetrahedron Lett. 31,4921 922. 

Role of Ascorbic Acid in a Mono-oxygenase Model (Udenfriend s System)... 

This mechanism represents a shortcut in biological mono-oxygenase enzyme systems that use O2 as oxygen atom sources and whose mechanism is much more complex because of the requirement to cleave O2. Non-porphyrinic binuclear methane mono-oxygenase model complexes are also able to activate methane in the same way (see Chap. 19). When S = RH, Groves originally proposed the well-known rebound mechanism in which the Fe =0 species removes an H atom from RH, then transfers OH to produce the alcohol ROH ... 

J. R. Lindsay Smith, D. N. Mortimer, The oxidation of organic compounds with lodosylbenzene catalysed by tetra(4-N-methylpyridyl)porphyrinatoiron(III) pentacation A polar model system for the cytochrome P450 dependent mono-oxygenases, J. Chem. Soc. Chem. Commun. (1985) 410. 

Table 6-4 Mono-oxygenation and Dehydrogenation of Organic Substrates via a Model System for the Cytochrome P-450 Mono-oxygenase/Reductase Enzymes"...

The classical endo-exo deconstruction model of pure cellulose is undergoing revision in light of the recent discovery of a family of copper-dependent polysaccharide mono-oxygenases from the GH61 family (Table 4.1) (Harris et al., 2010 Quinlan et al., 2011). These enzymes represent a novel mechanism to deconstruct cellulose in that they cleave cellulose oxidatively, unlike traditional acid/base catalyzed enzyme systems. Family GH61 enzymes can also provide powerful synergistic benefits to cocktails of traditional GH5, GH6, and GH7 enzyme mixtures (Harris et al., 2010). 

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