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Flavin Mono-Oxygenase FMO

Metabolism of the dietary lipid phosphatidylcholine by gut bacteria generates trimethylamine (TMA), which is then oxidized into trimethylamine N-oxide (TMAO) by hepatic flavin mono-oxygenase (FMO). FMO expression is induced by the BA nuclear receptor FXR, upon stimulation with BA. TMAO is implicated in the formation of atherosclerotic plaque through induction of upregulation of the expression of two macrophage scavenger receptors, CD36 and SR-Al 7° Additionally TMAO were recently shown to inhibit reverse cholesterol transport (RCT),... [Pg.132]

In addition to cytochrome P450s, hepatic microsomes contain another class of mono-oxygenases, the flavin-containing mono-oxygenases (FMO). These enzymes catalyse oxidation at nucleophilic nitrogen, sulfur and phosphorus atoms rather than oxidation at carbon atoms, e.g. for phenothiazines, ephedrine, norcocaine and the mono-ether and carbamate-containing pesticides. [Pg.510]

See other pages where Flavin Mono-Oxygenase FMO is mentioned: [Pg.10]    [Pg.169]    [Pg.10]    [Pg.169]    [Pg.120]    [Pg.54]    [Pg.346]    [Pg.296]   


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FMOs

Flavin mono-oxygenases

Flavines

Flavins

Mono-oxygenases

Oxygenases

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