Monkeys self-administration

Substance Abuse and Mental Health Services Administration The BASIS Report Marijuana Use Secondary to Other Substances of Abuse. Rockville, MB, Substance Abuse and Mental Health Services Administration, 2003 Tanda G, Munzar P, Goldberg SR Self-administration behaviour is maintained by the psychoactive ingredient of marijuana in squirrel monkeys. Nat Neurosci 3 1073— 1074, 2000... 

Wood RW, Grubman J, Weiss B Nitrous oxide self-administration by the squirrel monkey. J Pharmacol Exp Ther 202 491 99, 1977 Wood RW, Coleman JB, Schuler R, et al Anticonvulsant and antipunishment effects of toluene. J Pharmacol Exp Ther 230 407 12, 1984 World Health Organization The lCD-10 Classification of Mental and Behavioural Disorders Clinical Descriptions and Diagnostic Guidelines. Geneva, World Health Organization, 1992... 

Similarly, self-administration of MDMA in monkeys trained to self-administer amphetamine (Kamien et al. 1986) or in monkeys or baboons trained to self-administer cocaine (Beardsley et al. 1986 Lamb and Griffiths 1987) probably reflects a dopaminergic component to the pharmacology of MDMA. This would be consistent with current theories of dopamine involvement in the mechanism of action of drugs with dependence liability (Wise and Bozarth 1987). 

Beardsley, P.M. Balster, R.L. and Harris, L.S. Self-administration of methylenedioxymethamphetamine (MDMA) by Rhesus monkeys. Drug Alcohol Depend 18 149-157, 1986. 

Both amphetamine and cocaine have also been reported to support intracranial self-administration in the mesolimbic/mesocortical dopaminergic system. Rats will self-administer cocaine into the medial prefrontal cortex (Goeders and Smith 1983). while amphetamine is self-administered into the orbitofrontal cortex of rhesus monkeys (Phillips and Rolls 1981) and the nucleus accumbens of rats (Hoebel et al. 1983 Monaco et al. 1981). These data indicate that the mesolimbic/mesocortical dopaminergic system is involved in the initiation of stimulant reinforcement processes, and this work suggests that the region of the nucleus accumbens, more specifically the mesolimbic dopamine system, may be an important substrate for reinforcing properties of several psychomotor stimulant drugs. 

Phillips, A.G., and Rolls, E.T. Intracerebral self-administration of amphetamine by rhesus monkeys. Neurosci Lett 24 81-86, 1981. 

Woolverton, W.L. Effects of a D1 and D2 dopamine antagonist on the self-administration of cocaine and piribedil by rhesus monkeys. 

In other words, we do not have them self-administering these toxic doses. We have done it with some rhesus monkeys that were self-administering methamphetamine. If you give them a regime that depletes the dopamine and serotonin, and then see what alterations there are in self-administration, it does go down, but we have not looked at that. 

Balster, R.L. and Chait, L.D. The effects of phencyclidine on amphetamine stereotypy in rats, ju J. Pharmacol 48 445-450, 1978. Balster, R.L. and Woolverton, W.L. Continuous access phencyclidine self-administration by rhesus monkey leading to physical dependence. Psvchopha rmacoloav 70 5-10, 1980. 

Bergman, J., Madras, B.K., Johnson, S.E., and Spealman, R.D., Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys, J. Pharmacol. Exp. Then, 251, 150, 1989. 

Justinova, Z., Tanda, G., Redhi, G.H., and Goldberg, S.R., Self-administration of delta(9)-tetrahydro-cannabinol (THC) by drug naive squirrel monkeys, Psychopharmacology, 169, 135, 2003. 

Balster, R.L., Schuster, C.R. A comparison of d-amphetamine, /-amphetamine, and methamphetamine self-administration in rhesus monkeys. Pharmacol. Biochem. Behav. 1 67, 1973. 

Letchworth S.R., Nader M.A., Smith H.R., Friedman D.P., Porrino LJ. Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys. J. Neurosci. 21 2799, 2001. 

Nader M.A., Daunais J.B., Moore T. et al. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys initial and chronic exposure. Neuropsychopharmacology. 27 35, 2002. 

Nader M., Mach R. Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure. Psychopharmacology. 125 13, 1996. 

Wilson M., Schuster C. The effects of chlorpromazine on psychomotor stimulant self-administration in rhesus monkeys. Psychopharmacologia. 26 115, 1972. 

Mellow N., Kamein J., Lukas S., Mendelson J., Drieze J., Sholar J. Effects of intermittent buprenor-phine administration of cocaine self-administration by rhesus monkeys. J. Pharmacol. Exp. Ther. 264 530, 1993. 

Cosgrove K., Carroll M. Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys a behavioral economic analysis. J. Pharmacol. Exp. Ther. 301 Jun 2002, 2002. 

Balster, R. L., and Johanson, C. E. (1973) Phencyclidine self-administration in the rhesus monkey. Pharmacol. Biochem. Behav., 1 167-172. 

A series of DAT selective 3-phenyltropanes have been reported to have potential for treatment of cocaine abuse [33,36,37]. RTI-336,15 (reuptake IC50 — 4.1 nM) was the most potent among these tropane derivatives in locomotor activity and drug discrimination it was less stimulatory than cocaine, and had the slowest onset and longest duration of action. It also reduced self-administration of cocaine in rats and rhesus monkeys. Interestingly, in rhesus monkeys trained to self-administer cocaine, when coadministrated with either citalopram or sertraline, 15 produced significantly more robust reductions in cocaine self-administration compared with 15 alone [38]. 

Mecamylamine (a nicotinic receptor antagonist) Mecamylamine decreased intravenous nicotine self-administration under various procedures in rats and monkeys... 

Deneau GA, Inoki R (1967) Nicotine self-administration in monkeys. Ann N Y Acad Sci 142 277-279... 

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