Monamines

CgHjiN. Liquid, b.p. 79 C. Used as the hydrochloride, C HnN HCI, with m.p. 164°C. Tranylcypromine is an inhibitor of monamine oxidase and is administered orally in the treatment of depressive illness. 

Heat the amine with one or two mols of redistilled benzaldehyde (according as to whether the base is a monamine or diamine) to 100° for 10 minutes if the molecular weight is unknown, use 1 g. of the base and 1 or 2 g. of benzaldehyde. Sometimes a solvent, such as alcohol (5 ml.) or acetic acid, may be used. Recrystallise from alcohol, dilute alcohol or benzene. 

Mo-Molybdate Monactin [7182-54-9] Monamid LIP A MonamidLMA Monamid S Monamine Monarch processors Monateric... 

This scheme eliminates the process of converting bis(etherimide)s to bis(ether anhydride)s. When polyetherimides are fusible the polymerization is performed in the melt, allowing the monamine to distill off. It is advantageous if the amino groups of diamines are more basic or nucleophilic than the by-product monoamine. Bisimides derived from heteroaromatic amines such as 2-arninopyridine are readily exchanged by common aromatic diamines (68,69). High molecular weight polyetherimides have been synthesized from various N,lSf -bis(heteroaryl)bis(etherimide)s. 

The oxazoloquinoline 629 was obtained from 7-formyloxazoloquinoline 628 as shown in Scheme 107. The inhibition of monamine oxidase by 629 was studied (97FRP2737206). 

Incorporation of the phenethyl moiety into a carbocyclic ring was at first sight compatible with amphetamine-like activity. Clinical experience with one of these agents, tranylcypromine (79), revealed the interesting fact that this drug in fact possessed considerable activity as a monamine oxidase inhibitor and as such was useful in the treatment of depression. Decomposition of ethyl diazoacetate in the presence of styrene affords a mixture of cyclopropanes in which the trans isomer predominates. Saponification gives acid 77. Conversion to the acid chloride followed by treatment with sodium azide leads to the isocyanate, 78, via Curtius rearrangement. Saponification of 78 affords tranylcypromine (79). 

In the discussion of benzylamines, we have met medicinal agents that owe their activity to some particular functionality almost without reference to the structure of the rest of the molecule. The hydrazine group is one such function in that it frequently confers monamine oxidase-inhibiting activity to molecules containing that group. Such agents frequently find use as antidepressants. Thus, reduction of the hydrazone of phenyl-acetaldehyde (84) affords the antidepressant phenelzine (85). Similar treatment of the derivative of phenylacetone (86) gives pheniprazine (87). ... 

Iodine Nitrides. There are two compds of interest, the triiodide the triiodide monamine, both of which are very sensitive expls ... 

There is an increase in anticholinergic effects when antihistamines are administered with the monamine oxidase inhibitors (MAOIs) and additive sedative effects if administered with central nervous system depressants (eg, narcotic analgesics or alcohol). When cimetidine and loratadine are administered together there is a risk for increased loratadine levels. 

Antipsychotics, bromocriptine, carbamazepine, chlorpropamide, cyclophosphamide, desmopressin, ecstasy, lamotrigine, monamine oxidase inhibitors, NSAIDs, oxcarbazepine, oxytocin, tricyclic antidepressants, selective serotonin reuptake inhibitors, vasopressin, vinblastine, and vincristine... 

Here then is the logic behind the first version of the chemical-imbalance theory. Iproniazid is a monamine oxidase inhibitor - it inhibits the oxidation of norepinephrine and serotonin in the synapses, thereby leaving more of these neurotransmitters available in the brain. When depressed people take iproniazid, they get better. Therefore insufficient norepinephrine and/or serotonin causes depression.12... 

Quaternary amine (or choline ester) Monoamine (a catecholamine) Monamine (a catecholamine) Secondary amine (a catecholamine) Monoamine (an indoleamine) Monoamine (an imidazoleamine)... 

MAOI non-selective monoamine oxidase (A/B) inhibitors RIMA reversible inhibitor of monamine oxidase type A SSRI selective serotonin (5-HT) reuptake inhibitors SNRI serotonin/noradrenaline reuptake inhibitor SNARI selective noradrenaline (NA) reuptake inhibitor NA = 5-HT — DA potency of the drug is very similar in raising the level of both (or all three) monamines NA > 5-HT more selective for NA 5-HT>NA more selective for 5-HT NA increases the release of NA. 

Zl. Zeller, E. A., Some remarks about monamine oxidase and monoamine inhibitors. J. Neuropsychiat. Suppl. 1, 125-130 (1960). 

Xanthene oxidase Monamine oxidase Diamine oxidase Cytosol Mitochondria Cytosol... 

In order to increase the external validity of our models, it might be desirable to consider some nonnicotine ingredients of tobacco smoke. It appears that there are natural monamine oxidase (MAO) inhibitors in tobacco smoke (Lewis et al. 2007). It would be interesting to determine whether the coadministration of a low dose of a standard MAO inhibitor along with chronic nicotine would increase physical dependence, as assessed by various withdrawal measures, hi view of the antidepressant properties of MAO inhibitors, measures reflecting aspects of depression might be particularly affected. 

Falk, B. (1962) Observations on the possibilities of the cellnlar localization of monamines by a flnorescence method. Acta Physiol. Scand. 56,19-25. 

Monamines are inactivated into aldehydes by amine oxidase (monoamine oxidase, MAO ) with deamination and simultaneous oxidation. MAO inhibitors therefore play an important role in pharmacological interventions in neurotransmitter metabolism. 

Hypersensitivity to maprotiline or mirtazapine coadministration with monamine oxidase inhibitors (MAOIs). 

Hypersensitivity to any component of this medication or to clonidine concurrent monamine oxidase inhibitor therapy. 

By using the iodide of a ladicid different om that already contained in the primary monamine, secondary monamines may he formed containing two different radicate, thus s—... 

Xhmatim.— j acting upon the secondary monamines with the iodides of the monad positive radicals, and subsequent treatment with potassio hydrate... 

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