Molecular robot

Oxazaborolidines (39), readily accessible from the amino acids (/ )-or (5)-proline (38), have been described as chemoen/ymes or molecular robots as a result of their mode of catalytic activity. 

Lund K, Manzo AJ, Dabby N, Michelotti N, Johnson-Buck A, Nangreave J, Taylor S, Pei R, Stojanovic MN, Walter NG, Winfree E, Yan H (2010) Molecular robots guided by prescriptive landscapes. Nature 465 206-210... 

Tweezers, scissors and screwdrivers are primitive tools compared to computers, but their importance and wide applicability to daily life cannot be ignored. Similarly, molecular scale mechanical devices would be very useful in nanotechnology. For example, a molecular robot that fabricates molecular wires and molecular machines that could penetrate deep inside the body would provide huge contribution in the fields of molecular electronics and medicine, respectively. 

G.M. Whitesides, The Once and Future Nanomachine. Biology Outmatches Futurists s Most Elaborate Fantasies for Molecular Robots , Sci. Am., 285,78 (2001)... 

Lund, K., Manzo, A.J., Dabby, N., Michelotti, N., Johnson-Buck, A., Nangreave, J., et al., 2010. Molecular robots guided by prescriptive landscapes. Nature 465, 206. 

Muscat, R.A., Bath, J., Turberfield, A.J., 2011. A programmable molecular robot. Nano Lett. 11, 982. 

Theoretical assessments of DNA-based computation by self-assembly indicate computation power far beyond that which has yet been experimentally implemented. Still, it remains to be seen if DNA computers will ever find a computational niche in which they can efficiently compete with electronic computers. One realm in which algorithmic DNA self-assembly appears to provide very great promise is in the nanofabrication of specific aperiodic structures for templating of nanoelectronics devices. Such nanopatterned materials could be used not only for communications and computational devices but also for sensors, biosensors, medical diagnostics, and molecular robotics applications. 

The provision of these office automation tools to the scientist must be done in a way which integrates the office activities with the lab activities. Global planning must be done for the implementation of a comprehensive system which includes laboratory Instruments, robotics, office automation, graphics, molecular, reaction and other modeling tools, information retrieval and all the other computer resources required by the modern scientist. 

The Rosetta mission with its planned landing on a comet, with analysis of cometary material (see Sect. 3.2), should provide more information on the occurrence of chiral molecular species in the cosmos (Adam, 2002). The GC-MS apparatus installed in the robotic lander RoLand is also able to separate and analyse chiral organic molecules (Thiemann and Meierhenrich, 2001). 

The European Molecular Biology Laboratory s (EMBL s) offers a well-equipped pro-teomics laboratory in its facilities at the Proteomics Visitor Facility (Heidelberg, Germany). The services in MB concern protein isolation, imaging, and robotics sample preparation, supported by some other analytical facilities. 

Montone KT, Brigati DJ, Budgeon LR. Anatomic viral detection is automated the application of a robotic molecular pathology system for the detection of DNA viruses in anatomic pathology substrates, using immunocytochemical and nucleic acid hybridization techniques. Yale J. Biol. Med. 1989 62 141-158. 

Scientists study protein motors because they are biologically interesting but also because they offer insights into mini-motors. Molecular machinery such as nanorobots or nanobots—tiny robots—is a major goal of nanotechnology, and it would have tremendous applications in a lot of fields, especially in medicine. Some researchers are trying to adapt protein motors to perform additional jobs, while other researchers simply use these tiny motors for inspiration. Ever since the 1966 film Fantastic Voyage, in which scientists shrank a team of specialists and a submarine and injected them into the body of a patient, people have been fascinated with potential treatments that would be made possible by tiny machines. 

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