Molecular recognition molecules

Moisture absorptivity, 17-45 Molar conductivity AMPS, 305-6 PAMPS, 305-6 temperature dependence, 306 Molecular imprinting resins, 293, 295, 296 Molecular imprinting technique, 289, 290, 291 Molecular orientation, 395 Molecular permeation, 135 Molecular recognition capability, 290 Molecular recognition information, 290 Molecular recognition molecules, 289 Molecular recognition sensor, 296 Molecular stifiening concept, 38 Molecular valves, stimuli-responsive sur ce as, 135-6... 

A large number of studies concerned witli tliiol-tenninated molecules has been directed at tire preparation of tailored organic surfaces, since tlieir importance has been steadily increasing in various applications. Films of o> functionalized alkanetliiols have facilitated fundamental studies of interfacial phenomena, such as adhesion [190, 191], corrosion protection [192], electrochemistry [193], wetting [194], protein adsorjDtion [195, 196] or molecular recognition [197, 198, 199, 200 and 201] to mention only a few. 

According to these basic concepts, molecular recognition implies complementary lock-and-key type fit between molecules. The lock is the molecular receptor and the key is the substrate that is recognised and selected to give a defined receptor—substrate complex, a coordination compound or a supermolecule. Hence molecular recognition is one of the three main pillars, fixation, coordination, and recognition, that lay foundation of what is now called supramolecular chemistry (8—11). 

Substrates involved in molecular recognition may feature a particular shape, size, state of charge, chemical affinity or optical specification (19,30,33—36). In general most of these parameters share. Nevertheless there may be dominating features of a certain substrate molecule to be used by a complementary receptor in the recognition process (9). 

This mode of molecular recognition, on principle, is defined as the recognition of like from unlike or self from unself-molecules, embodied in the spontaneous selection and preferential assembly of like components in a mixture (9). 

G. Van Binst, ed.. Design and Synthesis of Organic Molecules Rased on Molecular Recognition, Springer, New York, 1986. 

The present review intends to be illustrative rather than comprehensive, and focuses on the results of this study leading to the hypothesis 9 — the three-dimensional shape similarity between interacting groups in reacting molecules is responsible for more specific and precise molecular recognition than would otherwise be achieved — and on the explanation of biological recognition on this basis. 

Paldus J, Li X (1999) Electron Correlation in Small Molecules Grafting Cl onto CC. 203 1-20 Paleos CM, Tsiourvas D (2003) Molecular Recognition and Hydrogen-Bonded Amphiphilies. 227 1-29... 

Finally, to produce the structural and functional devices of the cell, polypeptides are synthesized by ribosomal translation of the mRNA. The supramolecular complex of the E. coli ribosome consists of 52 protein and three RNA molecules. The power of programmed molecular recognition is impressively demonstrated by the fact that aU of the individual 55 ribosomal building blocks spontaneously assemble to form the functional supramolecular complex by means of noncovalent interactions. The ribosome contains two subunits, the 308 subunit, with a molecular weight of about 930 kDa, and the 1590-kDa 50S subunit, forming particles of about 25-nm diameter. The resolution of the well-defined three-dimensional structure of the ribosome and the exact topographical constitution of its components are still under active investigation. Nevertheless, the localization of the multiple enzymatic domains, e.g., the peptidyl transferase, are well known, and thus the fundamental functions of the entire supramolecular machine is understood [24]. 

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