Molecular pharmacology signaling, pharmacological

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The present review will outline the molecular pharmacology of the mGluRs. Particular emphasis will be paid to the molecular mechanisms underlying mGluR signaling and the regulation of it mediated by intracellular proteins. 

Miyoshi K, Das AK, Fujimoto K, Horio S, Fukui H. Recent advances in molecular pharmacology of the histamine systems regulation of histamine HI receptor signaling by changing its expression level. J Pharmacol Sci 2006 101 3-6. 

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Ostrom, R. S., and Insel, P. A. (2004). The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling Implications for molecular pharmacology. 

These developments have been described and discussed in the reviews cited above which should be consulted for details, in particular as regards molecular biology, signal transduction mechanisms, pharmacological and physiological implications of the discovery of cannabinoid receptors [5-15],... 

New DC, Wong YH. The ORLl receptor molecular pharmacology and signalling mechanisms. Neurosignals 2002 11 197-212. 

Galve-Roperh, I., Rueda, D., Gomez del Pulgar, T, Velasco, G., and Guzman, M. (2002) Mechanism of extracellular signal-regulated kinase activation by the CBj cannabinoid receptor. Molecular Pharmacology 62 1385-1392. 

Vidi, P., Watts, V. (2009). Fluorescent and bioluminescent protein-firagment complementation assays in the study of G protein-coupled receptor oligomerization and signaling. Molecular Pharmacology, 75, 733-739. 

Berchiche, Y. A., Gravel, S., Pelletier, M. E., St-Onge, G., Heveker, N. (2011). Different effects of the different natural CC chemokine receptor 2h hgjinds on beta -arrestin recruitment, G alpha i signaling, and receptor internalization. Molecular Pharmacology, 79(3), 488-498. 

D., Vischer, H.F., Mattick, C., Leurs, R., and Smit, M.J. (2006) Chemokine-directed trafficking of receptor stimulus to different g proteins selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51. Molecular Pharmacology, 69, 888-898. 

Yang, Q., Alemany, R., Casas, J., Kitajka, K., Lanier, S. M. Escriba, P. V. (2005). Influence of the membrane lipid structure on signal processing via G protein-coupled receptors. Molecular pharmacology, 68(1), 210-7. 

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