G protein-coupled receptors oligomerization

G-protein-coupled receptor oligomerization and its potential for drug discovery. Nature Reviews Drug discovery, 1, 808-820. 

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Overton, M. C. and Blumer, K. J. (2002) The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J. Biol. Chem. 277,41463-41472. 

Park, P.S., Filipek, S., Wells, J.W. and Palczewski, K. (2004) Oligomerization of G protein-coupled receptors past, present, and future. Biochemistry, 43, 15643-15656. 

Javitch, J. A. (2004). The ants go marching two by two Oligomeric structure of G-protein-coupled receptors. Mol. Pharmacol. 66, 1077-1082. 

Abstract Dimerization, and more generally oligomerization, of G protein-coupled receptors... 

Park PSH, Palczewski K (2005) Diversifying the repertoire of G protein-coupled receptors through oligomerization. Proc. Natl. Acad. Sci. USA 102(25) 8793—8794... 

Another source of variation is the oligomeric state of G protein-coupled receptors. In Figure 8.1, the receptor is depicted as a monomeric molecule, and indeed this was the prevailing model until fairly recently. However, it is now clear that very many GPCR are indeed oligomeric. This has several consequences ... 

The general assumption that receptor dimerization and oligomerization were important processes only for large polypeptide hormones and growth factors has been tempered with the realization that G-protein-coupled receptors may also function physiologically and pathologically as homo- and hetero-dimers. " ... 

Nijmeijer, S., Leurs, R., Smit, M. J., Vischer, H. F. (2010). The Epstein-Barr virus-encoded G protein-coupled receptor BILFl hetero-oligomerizes with human CXCR4, scavenges Galphai proteins, and constitutively impairs CXCR4 functioning. Journal of Biological Chemistry, 285, 29632—29641. 

Klco, J.M., Lassere, T.B., and Baranski, T.J. (2003) C5a receptor oligomerization. 1. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. The Journal of Biological Chemistry, 278, 35345-35353. 

Bouvier, M., Oligomerization of G-protein-coupled transmitter receptors, Nat. Rev. Neurosci., 2(4), 274—286, 2001. 

Cheng, Z. J. and Miller, L. J. (2001) Agonist-dependent dissociation of oligomeric complexes of G protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer. J. Biol. Chem. 276,48040-48047. 

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