Molecular pharmacology definition

D. Molecular Orbital Calculations. Pharmacological Activity of Meso-ionic Compounds Meso-ionic— Definition and Delineation... 

A definite and strong relationship seems to exist between the molecular structure of most pharmacologic compounds and their inherent pharmacologic properties. For example, modifying the molecular structure of acetylcholine dramatically alters its pharmacologic properties. Acetylcholine... 

Comparative structural analysis of sodium channel genes has permitted the development of testable hypotheses concerning the neurotoxin recognition properties of the sodium channel protein. However, specific elements of the deduced structure have not yet been definitively correlated with the molecular recognition of sodium channel-directed neurotoxins by discrete binding domains. It is, thus, not possible at the present time to know which pharmacological properties are determined by the sodium channel protein per se and which are determined by interactions between it and crucial features of its membrane environment. Clearly, it will be necessary to analyze the effects of specific modifications of sodium channel structure in a defined membrane environment in order to address these and other questions relating to sodium channel function. 

Emil Fischer, 1894.Advances over the past several decades have provided not only a better pharmacological understanding of drug-receptor interactions, but also have defined approaches to the quantitation of drug-receptor interactions, definitions and interpretations of structure-activity relationships and, through advances in molecular biology, have provided sequences and three-dimensional... 

A close watch is also being kept on the thiazide diuretics, where through molecular modification vastly more potent diuretics have been created. So far, in my experience, and from what has appeared in the literature, there seems to be a lessening incidence of serious adverse, allergic, and other toxic effects other than those inherent in the drug s action, as the potency is increased and the dose decreased. Since allergy and other toxic effects, except those inherent in the molecule s pharmacological action, are so small in the case of the steroid hormones, no definite trend can be seen in that series of compounds as yet. 

A definite and strong relationship seems to exist between the molecular structure of most pharmacologic compounds... 

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