Molecular host-guest chemistry

In contrast, in the non-swollen form (pH < 6.5), there is no apparent exchange of large molecules between the cavity and the bulk medium. This transition can be viewed as analogous to reversible gating in molecular host-guest chemistry, " with the potential for se-... 

As it is currently practiced, supramolecular chemistry, with its emphasis on the interactions between molecules, underpins a very wide variety of chemistry and materials science impinging on molecular host-guest chemistry, solid-state host-guest chemistry, crystal engineering and the understanding and control of the molecular solid state (including crystal structure calculation), supramolecular... 

The main aim in host-guest chemistry is to construct molecular receptors by a self-assembly process so that such receptors could, to some extent, gain molecular recognition capability. The goal of such molecular recognition capability is to either mimic or block a biological effect caused by molecular interactions [157]. 

Supramolecular chemistry takes into consideration the weak and reversible non-covalent interactions between molecules, which include H-bond-ing, metal coordination, hydrophobic forces, van der Waals forces, n—n interactions, and covers different research fields, for example, molecular recognition, host-guest chemistry, mechanically interlocked and nanochemistry. 

The exploitation of the reactivity of molecular crystals lies close to the origins of crystal engineering and is at the heart of the pioneering work of Schmidt [47a]. The idea is that of organizing molecules in the solid state using the principles of molecular recognition and self-assembly. Successful results have been obtained with bimolecular reactions, particularly [2+2] photoreactivity and cyclisation [47b,c]. Another important area is that of host-guest chemistry. 

Noncovalent interactions play a special role in synthetic procedures used to assemble various types of supramolecular species. These syntheses rely on the stabilization provided by non-covalent interactions between recognition sites incorporated within precursors. Various types of non-covalent interactions can be used as a recognition motif utilized to guide the synthesis.Targeted synthesis of macro- and supramolecular structures of various sizes, shapes, and functionality has now become possible. Supramolecular chemistry offers incredible applications in various fields such as medicinal chemistry (drug delivery systems),host-guest chemistry,catalysis,and molecular electronics. ... 

PEDERSEN, CHARLES JOHN (1904-1989). An American bom in Korea, Pedersen received a M.S. from M.I.T. in 1927. In 1987 he was awarded the Nobel Prize for Chemistry for his work in elucidating mechanisms of molecular recognition, which are fundamental to the enzymic catalysis, regulation and transport. He reported that alkali metal ions could be bonnd by crown ethers into a more rigid, layered structure, in which the alkali metal ion was bound into the center of the ring. This field of study is called host-guest chemistry,... 

---