Modification, chemical reactivity hazard

The documentation should include the basic process knowledge and design considerations that form the foundation for facility design and operation. Prior to design, it is essential that this documentation be as complete as possible, since the identification and control of chemical reactivity hazards will be developed from this information. As subsequent knowledge is obtained or developed as a result of process or technology modification, it should also be incorporated into the documentation and carefully reviewed. 

Certain structural features, including whether it contains functional groups such as aldehydes, ketones, nitriles, or isocyanates, often define a class of chemicals. If information on the mechanism of action of a hazardous property of a chemical is not known, or if variances in the chemical s hazard through structural modification cannot be determined, then the assumption that certain chemically reactive functional groups can react similarly with the body or in the environment is often a good starting point in the process of evaluating the safety of solvents. 

---