Model tissue adhesive

Results of Various Test Methods Using MFC as a Model Tissue Adhesive... 

Goatskin Model A layer of paraffin wax was molded into the bottom of polypropylene containers. The goatskin was dissected from the subcutaneous tissue, stretched to its original dimensions, and pinned onto the wax layer. The container was then filled with a saline solution (0.9% w/vol. NaCl and 0.05% w/vol. NaNg) until the skin was totally submerged. The sample was stored in a freezer at -10°C. Prior to use, the sample was removed from the freezer and thawed at room temperature. The saline was poured from the container. A lint-free tissue was used to remove excess moisture. A 19-cm incision was made down the length of the sample. The skin around the incision was approximated and 400 pL of a cyanoacrylate tissue adhesive... 

Nylon Peel Test Nylon-6 films (10-mil Ihick) were pressed between Teflon-covered stainless steel plates on a 30-ton Carver hydraulic press at 235°C. The nylon film was then cut into 2 x 5 in panels, with care taken to ensure all sides were square. The panels were submerged in a phosphate buffer solution (pH = 7.2, T = 25°C) for 1 h. Excess moisture was removed with lint-free tissue paper. The monomeric tissue adhesive, for example MFC, was applied to one panel, and another panel was placed on top. A 1/2 x 5 in portion of the panels was left unglued. The MFC was allowed to cure for 2 h. Each panel was then sectioned into smaller samples. The xmglued portion was gripped into an MTS MiniBionix (Model 858) and the force required to separate the films at a displacement rate of 2.5 cm/min was measured. The average load after the initial peak was used to calculate the average peel force of the adhesive joint. 

Using an incisional rat skin wound model, performance of absorbable tissue adhesives was compared against (1) sutures and staples and (2) a commercial, nonabsorbable tissue adhesive. 

In a study conducted in China,animal model was used to assess the efficacy of sutureless anastomoses using tissue adhesives. The two cut ends of the rabbit common carotid artery were sutured by three stitches with a 1208 interval circumferentially. Then two optional threads were pulled horizontally and 0.1 mL of CA adhesive was smeared on the attached surfaces of the two ends. The three stitches were removed after completion of anastomosis. The burst pressure of the... 

Tissue Adhesive for Closure of Hernia Incisions The study in Ref. [95] intended to elucidate that suture-based permanent mesh fixation can be replaced by fixation with n-butyl-2-cyanoacrylate glue (Glubran 2 by GEM S. r. 1., Italy) for surgical repair of abdominal waU hernias. The aim of this study was to investigate in a rat animal model the efficacy of the use of a small amount of modified ra-butyl-2-cyanoacrylate... 

Finite-element techniques can cope with large, highly non-linear deformations, making it possible to model soft tissues such as skin. When relatively large areas of skin are replaced during plastic surgery, there is a problem that excessive distortion of the apphed skin will prevent adequate adhesion. Finite-element models can be used to determine, either by rapid trial-and-error modelhng or by mathematical optimisation, the best way of... 

An anti-intracellular adhesion molecule-1 (anti-ICAM-1) antibody reduced neurological damage in a rabbit embolic model of stroke followed by thrombolysis with tissue-type plasminogen activator (tPA). When thrombolysis was delayed for 3 h following embolism, neither tPA nor the tPA/ICAM combination reduced neurological damage. 

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