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Mobile phase binary blend

Solvent optimization in reversed-phase liquid chromatography is commenced by selecting a binary mobile phase of the correct solvent strength to elute the seuaple with an acceptable range of capacity. factor values (1 < k <10 in general or 1 < k < 20 when a larger separation capacity is required). Transfer rules (section 4.6.1) are then used to calculate the composition of other isoeluotropic binary solvents with complementary selectivity. In practice, methanol, acetonitrile and tetrahydrofuran are chosen as the selectivity adjusting solvents blended in different... [Pg.755]

Binary eluent. A two-solvent blend used as the mobile phase. [Pg.19]

When developing a separation, the first tactic is to search for the best binary solvent combination. But sometimes the first choice for the strong solvent does not work out as well as it did in the problems addressed in Figures 5-1 and 5-2. In certain situations blending two solvents may not result in a mobile phase in which a particular separation is possible. It is, therefore, necessary to try a new binary mixture. An example of this is the separation of the steroids shown in Table 5-1, where both water/methanol and water/ acetonitrile combinations are used. Examining Table 5-1 shows that the hydrocortisone acetate and dexamethasone are particularly troublesome. [Pg.135]

Like binary blends, PA6/(g-PE/g-EPDM) composites are two-phased. Irrespective of the components ratio, their individual effects of melting and crystallization in blends are shown on the DSC curve. The comparative analysis of structure-morphology features for ternary blends, PA6/(g-PE/g-EPDM), and binary blends indicated that g-EPDM added to PA6/g-PE affects crystallization of the polyolefin as well as polyamide components. The results of DSC on the two types of blends, PA6/ (g-LDPE/g-EPDM) and PA6/(g-HDPE/g-EPDM), show increased crystallinity in g-PE against a binary blend (108,109). This effect results, most likely, from easier crystallization of g-HDPE in the presence of g-EPDM owing to raised molecular mobility because of plasticization by the elastomeric phase. [Pg.546]

To prepare TLC mobile phases, solvents from the elutropic series are blended into binary or ternary mixtures of the correct strength. In most cases, the strength of a solvent mixture will be intermediate between the strengths of the two (or more) components of the mixture. In addition to the proper strength, the mobile phase must also provide adequate selectivity to achieve the required separation. [Pg.92]


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Binary blends

Mobile phase binary

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