Vindesine Mitomycin

Furuse K, Fukuoka M, Kawahara M, et al. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III nonsmall cell lung cancer. J Clin Oncol 1999 17 2692-2699. 

CyEP, cyclophosphamide/etoposide/cisplatin EP, etoposide/cisplatin NCI, National Cancer Institute PIM, cisplatin/ifosfarnide/mitomycin VdP, vindesine/ cisplatin preop., preoperatively postop., postoperatively ChT, chemotherapy NS, not significant. 

A fatal case of mitomycin C-induced pneumonitis has been reported in a radiotherapy/chemotherapy trial in 43 patients (4). The dose was 8 mg/m on days 1 and 29, radiotherapy and vindesine being given on the intervening days. 

Acute shortness of breath and bronchospasm have been reported after the administration of vinca alkaloids, for example vinblastine and vindesine (30-34). The respiratory effects, including abrupt onset of progressive dyspnea, non-productive cough, pleuritic chest pain, profound wheezing, and diffuse basal crackles, were more common when mitomycin was used concomitantly. The onset of symptoms can be rapid (for... 

Prestifilippo J, Lewin D. Dyspnea following vinblastine or vindesine administration in patients receiving mitomycin plus vinca alkaloid combination therapy. Cancer Treat Rep 1984 68(7-8) 1029-31. 

Vinblastine and vindesine can increase the pulmonary toxicity of mitomycin C. Severe and life-threatening bronchospasms and two cases of fatal acute respiratory failure have been reported. 

Rarely, azathioprine and its major metabohte 6-mercaptopurine have been reported to produce an acute restrictive lung disease. Procarbazine, a methylhydrazine associated more commonly with Loef-fler s syndrome, rarely has been associated with pulmonary fibrosis. The vinca alkaloids vinblastine and vindesine have been reported to produce severe respiratory toxicity in association with mitomycin. The incidence with the combination is 39% and may represent a true synergistic effect between these agents. ... 

A syndrome of acute pulmonary toxicity, characterised by severe shortness of breath, can occur when vinblastine, vindesine or vinorelbine is given with mitomycin. Fatalities have occurred. 

Luedke D, McLaughlin TT, Daughaday C, Luedke S, Harrison B, Reed G, Maitello O. Mitomycin C and vindesine associated pulmonaiy toxicity with variable clinical esqrressiotL Cancer( 9%5) 55,542-5. 

---