Miscarriage, recurrent

XIII Umbilical cord, intracranial, and joint bleeding recurrent miscarriages, impaired wound healing Normal PT, aPTT, thrombin time, bleeding time Specific factor XIII assay... 

Whereas (32 glycoprotein 1 ((J2-GPI) is the target of anticardiolipin antibodies, prothrombin is the antigen for most lupus anticoagulants. Both these antibodies are risk factors for both venous and arterial thrombosis. In addition, complications such as thrombocytopenia and recurrent miscarriages are manifestations of the so-called antiphospholipid syndrome (97). 

Q67 When habitual abortion is due to incompetence of the cervix, suturing of the cervix may be adopted. Dydrogesterone is recommended as a first-line treatment in patients with a history of recurrent miscarriage. 

Arnold, J., Holmes, Z., Pickering, W., Farmer, C., Regan, L., and H. Cohen, 2001, Anti-beta 2 glycoprotein 1 and anti-annexin V antibodies in women with recurrent miscarriage. Br J Haematol. 2001 113(4) 911—4. 

Bizzaro, N., Tonutti, E., Villalta, D., Tampoia, M., and R. Tozzoli, 2005, Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages. Arch Pathol Lab Med.l29(l) 61-8. 

An important and recurrent concern on the part of the public is that of birth defects and miscarriages and whether they can be caused by herbicides such as 2,4-D. 2,4-D most... 

Folka ZJ, Lambropoulos AR Saravelos H, et al. Factor V Leiden and prothrombin G202I0 mutations but no methylenete-trahydrofolate reductase C677T are associated with recurrent miscarriages. Hum Reprod 2000 15(2) 458-462. 

Bulletti C, Flamigni C, Giacomucci E. 1996. Reproductive failure due to spontaneous abortion and recurrent miscarriage. Hum Reprod Update 2 118-136. 

AntiphosphoUpid syndrome is a constellation of various recurrent cUnical events as well as specific immunological features arterial and venous thrombosis, including recurrent ischemic stroke or TIA and intracranial venous thrombosis, migraine-Uke episodes, recurrent miscarriage, Uvedo reticularis, cardiac valvular vegetations, thrombocytopenia, false-positive... 

Young (<50 years) and no other cause found past history or family history of venous thrombosis, especially if unusual site (cerebral, mesenteric, hepatic veins) recurrent miscarriage thrombocytopenia cardiac valve vegetations livedo reticularis raised ESR malaise positive syphilis serology... 

Several hematologic disorders and hemostatic defects increase risk of ischemic stroke. Inherited thrombophilias (such as factor V Leiden protein S, protein C, or antithrombin III deficiency or the prothrombin G20210A mutation) rarely contribute to stroke in adults, but may play a larger role in pediatric stroke. Antiphospholipid antibody syndrome consists of venous and arterial occlusive disease in multiple organs, miscarriages, and livedo reticularis [7]. The association between antiphospholipid antibodies and stroke in the absence of antiphospholipid antibody syndrome is strongest for young adults. In the Antiphospholipid Antibodies in Stroke substudy of WARSS (WARSS/ APASS), antiphospholipid antibodies were detected in 40.7% of stroke patients, but they had no effect on the risk of stroke recurrence (see Table 2.5) [88]. Thrombotic thrombocytopenic purpura (TTP) has... 

Clifford K, Rai R, Watson H, Regan L (1994) An informative protocol for the investigation of recurrent miscarriage preliminary experience of 500 consecutive cases. Hum Reprod 9 1328-1332... 

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