Microencapsulation by spray drying

Spray drying. Microencapsulation by spray drying is an ideal method for poorly water-soluble drugs. The drug is dispersed in polymer (coating) solution, and then this dispersion is atomized into an airstream. The air, usually heated, supplies the latent heat of vaporization required to remove the solvent and forms the microencapsulated product. This technique is employed most commonly when microcapsules are intended for oral use because the resulting microspheres are porous in nature, and large batch sizes are required.89... 

For polymorphic compounds, such as sulfa drugs, talc excipients induced polymorphic transformation of sulfamethoxazole during the process of microencapsulation by spray-drying,... 

Re Ml, Liu YJ. 1996. Microencapsulation by spray drying Influence of wall systems on the retention of the volatiles compounds. In Proceedings of the 10th International Drying Symposium Drying 96), Krakow, Poland, pp. 541-549. 

Drusch S, Serfert Y, Scampicchio M et al. (2007) Impact of physicochemical characteristics on the oxidative stability of fish oil microencapsulated by spray-drying. Journal of Agricultural and Food Chemistry 55 11044-11051. 

Saenz, C., Tapia, S., Chavez, J., Robert, R, 2009. Microencapsulation by spray drying of bioactive compounds from cactus pear Opuntia ficus-indica). Food Chem. 114, 616-622. 

Ortiz, S.E.M., Mauri, A., Monterrey-Quintero, E.S., Trindade, M.A., 2009. Production and properties of casein hydrolysate microencapsulated by spray drying with soybean protein isolate. Food Sci. Technol. 42, 919-923. 

Sheu T.Y. and Rosenberg M., 1995. Microencapsulation by spray drying ethyl caprylate in whey protein and carbohydrate wall systems. Journal of Food Science, 60(1), 98-103. 

Soottitantawat A., Yoshii H., Furuta T., Ohkawara M., and Linko R, 2003. Microencapsulation by spray drying Influence of emulsion size on the retention of volatile compounds. Journal of Food Science, 68, 2256-2262. 

The microencapsulation by spray-drying involves four steps preparation of the dispersion or emulsion homogenization of the dispersion atomization of the mass into the drying chamber and dehydration of the atomized particles (Shahidi and Han, 1993 Gharsallaoui et al., 2007). 

Johansen P, Merkle HP, Gander B. Technological considerations related to the up-scaling of protein microencapsulation by spray-drying. European Journal of Pharmaceutics and Biopharmaceutics Official Journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. November 2000 50(3) 413 17. PnbMedPMID 11072199. 

The most popular method of pigments encapsulation is spray-drying. Many papers present information about microencapsulation by spray-drying, and this method is most frequently used to protect pigments obtained from vegetables, fruits, flowers, and plants, for example, black carrot, curcumin, beetroot, or roselle. Application of natural polymers as shell to protect beetroot color increased the half-life of spray dried dye about three times, whilst pink color was stabile for about 8 weeks. In case of red roselle pigments stabilization, after microencapsulation, it was acceptable to extend the storage time under different water activities up to 4 months. ... 

Microencapsulation by spray-drying is a low-cost commercial process which is mostly used for the encapsulation of fragrances, oils and flavors. Core particles are dispersed in a polymer solution and sprayed into a hot chamber (Fig. 1.15). The shell material solidifies onto the core particles as the solvent evaporates such that the microcapsules obtained are of polynuclear or matrix type. Very often the en-... 

Re MI. Microencapsulation by spray drying. Drying Technol 1998 16(6) 1195-1236. Wan LS, Heng PW, Chia CG. Spray drying as a process for microencapsulation and the effect of different coating polymers. Drug Dev Ind Pharm 1992 18(9) 997-1011. Sutinen R, Laasanen V, Paronen P, Urtti A. pH-controlled silicone microspheres for controlled drug delivery. J Controlled Release 1995 33 163-171. 

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