Miconazole nitrate vaginal

Miconazole nitrate vaginal suppositories contain not less than 90% and not more than 110%i of the labeled amount of C18H14CI4N2O HNO3. 

Xue et al. [30] prepared a vaginal suppository formulation containing miconazole nitrate and determined its content by P-matrix ultraviolet spectrophotometry. The production of the suppository was finished with melting by the excipient of glyceryl esters fatty acid of artificial synthesis. Quantitative assay was conducted with a P-matrix ultraviolet spectrophotometer. The suppository was smooth and met the clinical requirement of vaginal disease treatment. The method of assay was accurate. 

Gyno-Daktarin 200 mg vaginal capsule (Janssen-Cilag) miconazole nitrate Cleocin (Pharmacia) clindamycin phosphate... 

Brown, D., Henzl, M. R., and Kaufman, R. H. (1999), Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group, /. Reprod. Med., 44, 933-938. 

Miconazole nitrate is available as an ointment, cream, solution, spray, or powder (micatin, monistat-DERM, Others). To avoid maceration, only the lotion should be applied to intertriginous areas. It is available as a 2% and 4% vaginal cream, and as 100-mg, 200-mg, or 1200-mg vaginal suppositories (monistat 7, MONiSTAr3, others), to be applied at bedtime for 7, 3, or 1 day(s), respectively. 

Vaginal Chitosan gel formulation Econazole nitrate and Miconazole nitrate Efficient vaginal retention and release profile [98]... 

Miconazole nitrate, previously shown to be effective in topical treatment of Trichophyton infections, was effective when used topically for 1 to 5 weeks as a 2 cream in kk of k6 cases of Candida vaginitis, but it was without effect in 2 cases of vaginal Torulopsis glabrata. ... 

Econazole. Econazole and isoconazole are structurally very similar to miconazole they differ only in the pattern of chlorine substitution on the terminal phenyl ring. Chemically, econazole (Fig. 2, 7b) is closely related to miconazole. The clinical indications are almost identical. Econazole [27220-47-9] is available as a vaginal cream and ovule containing respectively 1% and 150 mg econazole nitrate. For mycoses of the skin, several forms are available including cream, spray-powder, spray-solution, and lotion. All these formulations contain 1% econazole nitrate [68797-31-9]. The dosages are practically identical to those of miconazole. 

Isoconazole. Tike econazole, both the chemical structure and the clinical indications of this imidazole derivative (Fig. 2, 7c) closely resemble those of miconazole. It is available as a vaginal tablet (300 mg isoconazole nitrate per tablet). In some countries isoconazole [27523-40-6] is also available as a cream for dermatological use and as a cream and ovules for treatment of vaginal candidosis. 

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