MIBK, synthesis

Synthesis of MIBK Synthesis of MTBE Removal of O2 from water ... 

MIBK synthesis Hydrotalcites/CNF Specific activity of supported hydrotalcites is found to be fonr times higher than that of unsupported catalysts. 353... 

Basic catalyst, MIBK synthesis 23-0-05 Bentonite zeolitisation 03-P-06... 

Preparation of new aiuminophosphate oxynitride (AlPON) and nickel modified AlPON are presented. Such basic and polyfunctional catalysts are tested in Knoevenagel condensation and one step synthesis of methylisobutylketone (MIBK) from acetone. It is evidenced that the nitrogen content of the AlPON, which controls the rate of benzaldehyde-ethylcyanoacetate condensation depends on the activation procedure. 90% selectivity in the MIBK synthesis is obtained on Ni formate impregnating AlPON activated at 400 °C for 4 hours. TPD of CO2 and NH3, DRIFT analysis and quantum mechanical calculation evidence that the 0/N substitution creates strong basic sites. 

Fig. 7. Selectivity in the acetone to MIBK synthesis in function of reduction time of the Ni-AIPON.

The activity of both Pd and sulfided Pt catalysts for the synthesis of N-(l,3-dimethylbutyl)-N-phenylamine from aniline and MIBK was lower than that with acetone. This could be attributed to the steric hindrance effect (14). The selectivity over sulfided Pt catalysts was higher compared to unsulfided Pd catalysts due to formation of byproducts as with aniline-acetone reaction. 

The reductive alkylation of 4-aminodiphenylamine with MIBK to yield 6-PPD have been studied previously (2,12,15). Greenfield showed that Pd, Pt and sulfided Pt are active for this reaction and Aranajatesan et al. showed that the optimal mole ratio of S/Pt is around 1.7. Again, we found that the sulfided Pt/C is an effective catalyst for the synthesis of 6-PPD. 

The present economic and environmental incentives for the development of a viable one-step process for MIBK production provide an excellent opportunity for the application of catalytic distillation (CD) technology. Here, the use of CD technology for the synthesis of MIBK from acetone is described and recent progress on this process development is reported. Specifically, the results of a study on the liquid phase kinetics of the liquid phase hydrogenation of mesityl oxide (MO) in acetone are presented. Our preliminary spectroscopic results suggest that MO exists as a diadsorbed species with both the carbonyl and olefin groups coordinated to the catalyst. An empirical kinetic model was developed which will be incorporated into our three-phase non-equilibrium rate-based model for the simulation of yield and selectivity for the one step synthesis of MIBK via CD. 

A CD process for the production of DAA from acetone was developed previously in our laboratory and the kinetics of the aldol condensation of acetone were characterized (13,14). CD is a green reactor technology that provides enhanced yield and selectivity in addition to significant energy savings (15). The one-step synthesis of MIBK by CD appears to be a simple extension of this process. However, the introduction of hydrogen to this system opens... 

Figure 1 CD processes for the one-step synthesis of MIBK from acetone. Experimental Section...

Synthesis of a PHBA-benzoic acid adduct. PHBA and benzoic acid in a 1 1.5 mol ratio were heated at 230+/-3° in the presence of 0.2 wt% of p-TSA and "Aromatic 150" as described above. The product mixture was cooled and diluted with an equal volume of a 1 1 mixture of "Aromatic 150" and cyclohexanone. The resulting paste was filtered, dried in an oven, pulverized, washed 5 times with hot water, and dried at 100°. The material was insoluble in hot MIBK. 

Aldol chemicals refer to a variety of substances desired from acetone involving an aldol condensation in a portion of their synthesis. The most important of these chemicals is methyl isobutyl ketone (MIBK), a common solvent for many coatings, pesticides, adhesives, and pharmaceuticals. Approximately 0.17 billion lb of MIBK were made in recent years. The synthesis is outlined on the next page. 

Figure 2. Undesirable consecutive reactions in the synthesis of MIBK...

The synthesis of an N-alkylarylamine by the reductive alkylation of an aromatic primary amine with a ketone is used in the preparation of antioxidants for polymers and rubber. The alkylation of an amine with a ketone is typically carried out in the liquid phase using heterogeneous catalysts such as Pd, Pt, Rh, or Ru supported on carbon (1,2). The reaction of ADPA with MIBK yields an imine, which then is hydrogenated over a Pt or sulfur promoted-Pt catalyst to yield 6-PPD. 

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