MHC system

Antigen-presenting cells (APCs) are cells of the immune system that are able to process and present foreign antigens to effector cells. The antigen is presented in the context of an MHC-I or MHC-II molecule on APCs in the presence of so-called costimulatory molecules to activate the effector cells. 

The human leucocyte antigen (HLA) system is the general name of a group of genes in the human major histocompatibility complex (MHC) region on human chromosome 6 (mouse chromosome 17) that encodes the cell-surface antigen-presenting proteins. 

The Liskamp group also examined the ability of peptoid-peptide hybrids to be bound by the MHC Class II receptor, an important component of the human immune system [39]. Two of three peptoid substitutions in the 14-residue peptide caused substantial decreases in binding affinity, despite the fact that these were solvent-exposed residues. These results were attributed to a loss of hydrogen-bond contacts as well as to steric clashes caused by unfavorable positioning of the new side chain groups. 

CBP Cromolyn-binding protein CCK Cholecystokinin CCR Creatinine clearance rate CD Cluster of differentiation (a system of nomenclature for sur ce molecules on cells of the immune system) cluster determinant CDl Cluster of differentiation 1 also known as MHC class I-like surfitce glycoprotein... 

Flajnik, M.F., and Kasahara, M., Comparative genomics of the MHC Glimpses into the evolution of the adaptive immune system, Immunity, 15, 351, 2001. 

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