11- Methyldodecanoic acid

Figure 7.19 Pathway for the synthesis for 2-methyldodecanoic acid (4) and 2-methyldodecanoic anhydride (8), used for research on correlation between selfreproduction and stereospecificty. (Adapted from Morigaki et al., 1997.)...

Thirty grams (0.14 mole) of 2-methyldodecanoic acid is bro-minated exactly as described in the preparation of 2-methylene-dodecanoic acid.2 The crude product, after the 18-hour heating period, is allowed to cool then 56 ml. (1.4 moles) of commercial absolute methanol is added at such a rate that the exothermic re-... 

The crude bromo ester is mixed with 82.5 ml. (0.70 mole) of pure quinoline (Note 3) in a 250-ml. round-bottomed flask equipped with an air condenser, and the mixture is heated for 3 hours with an oil bath maintained at 160-170°. The black mixture is cooled, treated with 150 ml. of 20% hydrochloric acid, then shaken thoroughly with 200 ml. of petroleum ether (Note 2) until most of the tarry material has dissolved (Note 4). The aqueous phase is separated and washed with an additional 200 ml. of petroleum ether, and the combined organic extracts are washed with 10% hydrochloric acid and then with water. This washing cycle is repeated until the washes are colorless (two acid washes usually suffice) finally, the petroleum ether solution is washed once more with water. The organic layer is dried over anhydrous sodium sulfate, the solvent is flash-distilled as described above, and the residual liquid ester is distilled through a 61-cm. Pod-bielniak-type column (Note 5). The colorless unsaturated ester (Note 6) distils at 153-154°/14.5 mm. after a small fore-run. The yield is 22-27 g. (70-85.5% based on 2-methyldodecanoic acid), 1.4520-31, Xmax 214 me 12,300, in hexane (Note 7), Xmax 217 mii, e 12,800, in 95% ethanol. 

C13H20O3 acetoacetic acid 3,7-dimethyl-2,6-octadienyr 10032-00-5 513.15 45.149 2 26493 C13H2602 2-methyldodecanoic acid 2874-74-0 542.21 47.954 2... 

N-Methyl-1,2-diphenylethylamine AND HYDROCHLORIDE, 34, 64 2-Methyldodecanoic acid, 38, 43, 47, 49 2-Methyl-2-dodecenoic acid, 38, 49,50 trans-2-Methyl-2-dodecenoic acid,... 

Hell-Volhard-ZeUnsky reaction. Allen and Kalm converted 2-methyldodecanoic acid into the a-bromo acid bromide by reaction with phosphorus tribromide and... 

Methyldodecanoic acid, 874, 975-976 (ran>2-Methyl-2-dodecenoic add, 976 Methyl elaidate, 1007 Methyleneatninoacetonitrile, 368, 400, 412... 

FIG. 13 Dependence of the phase transition temperature (7 ) of the vesicles on the composition of (R)- and (5)-2-methyldodecanoic acid. Total concentration of acid was 100 mM, and half of the carboxyl groups were ionized. (From Ref. 119.)... 

Dodecene-1 Ni/silica gel 2-Methyldodecanoic acid -f tridecanoic acid 28 [483]... 

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