5- Methyl-1,2,4-triazines

The cycloaddition reaction of 1,2,4-triazines N-oxides proceeds differently from the reaction of the corresponding 1,2,4-triazines. Thus the 1,2,4-triazine 4-oxide 55 acts only as a diene in the reaction with 1 -diethylaminopropyne to afford 2-methyl-4-(dimethylamino)pyrimidines 111. At the same time the 1,2,4-triazine 4-oxides 55 react with l-(dimethylamino)-l-ethoxyethylene by 1,3-dipolar cycloaddition to give 5-methyl-1,2,4-triazines 112 (78CB240). 

Phenoxy acids (2,4-dichlorophenoxy acetic acid, MCPA, and 2,4,5-trichlorophenoxy acetic acid) and similar acid herbicides (benzaton, dicamba, dichlorprop, and mecoprop) sulfonurea herbicides (chlorsulforon, metsulforon methyl, tribenuron methyl, and thifensulfuron methyl) triazine herbicides (methoxy-s-triazines, chloro-s-triazines, alkylthio-s-triazines) phenylurea herbicides (fenuron, monolinuron, and diuron), metabolites of the fungicide thiophanate-methyl (carbenazim and 2-aminobenzimidazole)... 

N,N-diallylmelamine , vasodilator. Rat, dog, man. Extensively metabolized. N-oxidation (triazine ring, reversible reaction) to form active metabolite, then deallylation and N-reduction (rat) direct deallylation (M) (all species) hydroxylation of allyl group N-methylation (triazine ring) then deallylation UP in urine. Species difference - man does not produce active metabolite, (N-hydroxy triazine derivative). 

ALKANOLAMNES - ALKANOLAMINES FROM OLEFIN OXIDES AND APHONIA] (Vol 2) 2-t-butylamino-4-ethylamino-6-methyl-thio-l,3,5-triazine [886-50-0]... 

A large number of hindered phenoHc antioxidants are based on the Michael addition of 2,6-di-/ f2 -butylphenol and methyl acrylate under basic catalysis to yield the hydrocinnamate which is a basic building block used in the production of octadecyl 3-(3,5-di-/ f2 butyl-4-hydroxyphenyl)propionate, [2082-79-3], tetrakis(methylene-3(3,5-di-/ f2 butyl-4-hydroxylphenyl)propionate)methane [6683-19-8], and many others (63,64). These hindered phenolic antioxidants are the most widely used primary stabilizers in the world and are used in polyolefins, synthetic and natural mbber, styrenics, vinyl polymers, and engineering resins. 2,6-Di-/ f2 -butylphenol is converted to a methylene isocyanate which is trimerized to a triazine derivative... 

Several triazinyl ketones isomerize to 4-acetamidopyrimidines. TTiis is seen in the C-acylation of 2,4,6-trimethyl-l,3,5-triazine (708) with benzoyl chloride in the presence of sodium amide to give the ketone (709) which undergoes a Dimroth-like rearrangement in boiling water to afford A-(2-methyl-6-phenylpyrimidin-4-yl)acetamide (710) it can be seen that the acylating agent determines the identity of the 6-substituent 64JHC145). 

Naphtho[ 1,2-h]thiophene-2-carboxylic acid synthesis, 4, 893 Naphthothiophenes synthesis, 4, 881, 907, 914 Naphthothiophenes, dihydrosynthesis, 4, 113 Naphtho[ 1,2-c]thiophenes synthesis, 4, 891 Naphtho[2, l-h]thiophenes synthesis, 4, 907 Naphtho[2,3-h]thiophenes synthesis, 4, 905, 908-909 Naphtho[ 1,8-de][l,2,3]triazine, 2-methyl-reactions... 

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