1,2,4-Triazine 3.5- dioxo-6-methyl-2,3,4,5-tetrahydro

H-Pyrazino[l,2-a][l,3,5]triazine, 2-amino-8-methyl-4,9-dioxo-cis-6,7-diphenyl-6,7,8,9-tetrahydro-... 

In this connection the possibility of oxidation of these substances to the tetrahydro derivatives should be mentioned. It was made use of by Thiele and Bailey for the preparation of 6-methyl-3,5-dioxo-2,3,4,5-tetrahydro-l,2,4-triazine (6-azathymine) (46) and only recently by Grundman et al. for that of 6-azauracil (42). 

Oxidation of the hexahydro to tetrahydro derivatives was mentioned in connection with the synthesis of 3,5-dioxo-l,2,4-triazines (e.g., Section II,B,2,a). The reverse procedure, hydrogenation of the tetrahydro derivatives, was used with 6-azauracil, 6-azathymine, and their iV-methyl derivatives. With all these compounds hydrogenation proceeds smoothly in the presence of Adams catalyst. Only the hydrogenation of l-methyl-6-azathymine was not successful. ... 

Chemical Name Sodium salt of (6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(methoxyimino)ace-tamido] -8-oxo-3-[[(1,4,5,6-tetrahydro-4-methyl-5,6-dioxo-as-triazin-3-yl)thio] methyl] -5-thia-1 -azabicycio [4.2.0] oct-2-ane-2-carboxylic acid... 

Most of the reported triazinothiadiazines have been prepared from 1,2,4-triazine derivatives. Treatment of amino-1,2,4-triazine 28 with chloroacetyl chloride in dioxane in the presence of triethylamine at 10 °C resulted in the formation of 6-methyl-4-(A -chloroacetamido)-3-thioxo-5-oxo-2,3,4,5-tetrahydro-l,2,4-triazine 29 and 3-methyl-4,7-dioxo-4,6,7,8-tetrahydro-l,2,4-triazino[3,4-A][l,3,4]thiadiazine 15 (Scheme 1) <2005JHC935>. 

Ceftriaxone Ceftriaxone, 7-[[(2-amino-4-lhiazolyl)-2-(Z)-(methyoximino)acetyl]amino]-8-oxo-3-[[(l,2,5,6-tetrahydro-2-methyl-5,6-dioxo-l,2,4-triazin-3-yl)thio]methyl]-5-thia-l-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.72), is synthesized by acylating 7-amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-l,2,4-triazin-5-on-3-yl)thio]methyl]3-cefem-... 

A suspension of 5-methyl-6,7-diphenyl-5,6,7,8-tetrahydropterin in aq. 0.1 N NaOH stirred 10 hrs. under Og 2-amino-8-methyl-4,9-dioxo-cw-6,7-diphenyl-6,7,8,9-tetrahydro-4H-pyrazino[l,2a]-j-triazine. Y 69.2% 94.3% after 60-70 days in water without NaOH. F. e. s. J. A. Jongejan, H. I. X. Mager, and W. Berends, Tetrahedron 31, 533 (1975). 

C2 5H2 3N5O5, 2-Acetamido-8-methyl-4,9-dioxo-6,7-diphenyl-6,7,8,9-tet-rahydro-4H-pyrazino[1,2-a]-s-triazine dihydrate, 41B, 336 C2 5H2 8INO2 f 2-Benzyl-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1 -phenylisoquinolinium iodide, 43B, 350 C26H19N3, 1,3,5-Triphenyl-1H-1,2,4-benzotriazepine, 44B, 246 C26H2oBr2Nfi, 1,1 -Azo-2-phenylimidazo[1,2-a]pyridinium dibromide, 38B, 86... 

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