Methyl diethyldithiocarbamate

Following a single oral dose of 250 mg to 15 subjects, mean peak plasma concentrations of 0.38 pg/ml of disulfiram, 0.77 pg/ml of diethyldithiocarbamic acid, 0.30 pg/ml of methyl diethyldithiocarbamate, and 1.7 pg/ml of diethylamine were attained in about 9 hours a mean peak plasma concentration of 22 pg/ml of carbon disulphide was reported at 6 hours there was considerable intersubject variability in the plasma concentrations (M. D. Faiman etai, Clin. Pharmac. Ther., 1984, 36, 520-526). 

Alternatively, an aqueous solution of sodium diethyldithiocarbamate (3.5%, 2 ml) or freshly prepared solution of dithizone in chloroform (0.1%, 10 ml) was added to sample A. The metal diethyldithiocarbamates (termed sample B) or metal dithizon-ates (termed sample C) thus formed were extracted in chloroform. The volume of chloroform extract was reduced to 1.0 ml. Aliquots (10 pi) each of sample B and sample C were chromatographed on plates coated with 0.25-mm layer of silica gel G using benzene -t methyl isopropylketone (50 1) and toluene -r chloroform (50 1), respectively, as mobile phases. Metal dithizonates were self-detected. The namral colored metal diethyldithiocarbamates were converted into brown spots by spraying... 

DBPMPO, 5-(di-/ -butoxyphosphoryl)-5-methyl-l-pyrroline-yV-oxide DCFH, dichlorodihydrofluorescin DDC, diethyldithiocarbamate... 

In a series of papers, Matsuda et al. [291-295] employed RAFT-SIP with immobilized benzyl N,N-diethyldithiocarbamate to form polymer brushes from styrene, methacrylamides, acrylamides and acrylates, NIPAM and N-vinyl-2-pyrrolidone on various surfaces. The SIP is initiated by UV irradiation of the surface-bonded dithiocarbamates. Thermoresponsive polymer brushes were prepared by the polymerization of NIPAM and investigated by XPS, wetting experiments and mainly SPM [294]. Patterned polymer brush layers were also prepared. When chloro-methyl styrene was used as a comonomer, RAFT-SIP resulted in branching. By control of the branching, spatio-resolved hyperbranching of a controllable stem/ branch design was realized (Fig. 9.32) [293, 295]. 

N, Al -Bis(2-pyridylinethyl)-l,2-ethanediamine N, Al -Bis((6-methylpyrid-2-yl)methyl)ethane-l,2-diamine N, Al-Bis(2-pyridylinethyl)ethylamine Bis(picolyl)(N-methylimidazol-2-yl)amine 2,2 -Bipyridine 2, 2 -Bipyridine-l,l -dioxide Decamethylcyclopentadienide N, Al-Diethyldithiocarbamate Al -(2-Carboxyethyl) saKcylideneamine N, Al -Bis(2-hyroxybenzyl)-Al, Al -bis(2-pyridylmethyljethylenediamine... 

Note PAN = 1-(2-pyridylazo)-2-naphthol DMG = dimethylglyoxime DPC = 1,5-diphenylcarbazide DADTC = diethylammonium diethyldithiocarbamate PMBP = 1-phenyl-3-methyl-4-benzoyl-pyrazolone-5 HDEHP = b/s-[2-ethylhexyl]phosphate TBP = tributyl phosphate. 

After several hours, tellurium bis[diethyldithiocarbamate] and methyl iodide in dichloromethane produced methyl tellurium bis[diethyldithiocarbamate] iodide2. 

The most widely applied reagents have been chelating agents which will complex with many metals, e.g. dithizone and the various thiocarbamate derivatives such as diethyldithiocarbamate and pyrrolidine dithiocarbamate. The latter agent as the ammonium salt (APDC) has been shown to complex some thirty elements [19] most of which can be readily extracted into various solvents. 4-Methylpentane-2-one (methyl isobutyl ketone or MIBK) is usually the favoured solvent because of its excellent compatibility with flames. The solubility of MIBK in water is not negligible and this limits the available concentration factor to ten higher molecular weight ketones (e.g. decan-2-one) offer better concentration factors and chloroform up to fifty times, but this latter solvent is only really suitable for electrothermal atomisation. 

The Inifer technique enables us to fulfil some requirements of polymer architecture even in some radical processes. An amplified form may be applied, the Iniferter variant, where the radical initiator simultaneously acts as a transfer and terminating agent. Otsu et al. used sulphides and disulphides (tetraethylthiuram disulphide, PhSSPh, Ph2S, PhCH2SSCH2Ph) [96] and carbamates (benzyl-A,A-diethyldithiocarbamate, p-xylylene-A,7V-diethyl-dithiocarbamate) [97] in the photopolymerization of methyl methacrylate and styrene, and phenylazotriphenylmethane in the polymerization of methyl methacrylate [98]. Living radical polymerizations yield polymers with defined end groups or the required block copolymers. 

Inorganic and methylated organoarsenic compounds have been converted to their diethyldithiocarbamate or trimethylsilyl derivatives prior to determination by gas chromatography. 

Figure 2 shows an example of separating organomercury using supercritical CO2. A 10-m X 50- tm-in-ner diameter SB-Methyl 100 column was used for the separation. Due to their poor solubility in supercritical carbon dioxide, monoorganomercury compounds were derivatized by diethyldithiocarbamate. An interface for a system consisting of SFC and atomic fluorescence spectrometry was developed for the detection of organomercurials. 

Lead is extractable from sea water by several procedures which are also suitable for the separation of other trace metals mentioned above. Highly selective methods are not known so far. Systems recommended for the extraction of lead are the resins Chelex-100 (chapter 2.3.3 S6), 2.3.461), 2.3.5 65), 2.3.9 86,87), ammonium pyrroli-dinedithiocarbamate/methyl isobutyl ketone (chapter 2.3.4 60,61), pyrrolidinedithio-carbamate with diethyldithiocarbamate/Freon TF (chapter 2.3.670), 2-Hydroxo-phenyl-(2)-azonaphtol (Hyphan) (chapter 2.3.671>, dithizone/chloroform (chapter 2.3.7 78)), and ethylene diamine triacetic acid/controlled pore glass (chapter 2.3.9 85)). 

The broad luminescence band can be quenched by a number of molecules such as methyl viologen [69,70], diethyldithiocarbamate [74], SCN [73], and I" [73]. Both hole quenchers (e.g., SCN") and electron quenchers (e.g., methyl viologen) are effective, implying both trapped electrons and trapped holes can be present on the surfaces. 

Methyl Violet 4-(2-Pyridylazo)resorcinol Phenylfluorone Diethyldithiocarbamate... 

Simplicity, rapidity, and specificity have caused adoption of atomic absorption as a standard method in water analysis. Often solutions must be concentrated prior to measurement. Freezing, evaporation, ion exchange, and solvent extraction techniques have been reported. This paper describes a method for concentrating ferric iron, copper, zinc, cadmium, and lead using sodium diethyldithiocarbamate and methyl isobutyl ketone. Data shows increase in sensitivity caused by (1) concentrating effect of extraction, and (2) choice of the ketone solvent in preference to water. Recovery data on various industrial waters indicate that the method is reliable, reproducible, and accurate. 

Sodium diethyldithiocarbamate (4) forms complexes with many metals which are more or less soluble in various organic solutions. Preliminary tests showed that at pH 2-3, the carbamate complexes of ferric iron, zinc, cadmium, copper, and lead are extractable from water with methyl isobutyl ketone. 

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