Methoxyflurane Aminoglycosides

Drugs that may affect aminoglycosides include cephalosporins, enflurane, methoxyflurane, vancomycin, indomethacin IV, loop diuretics, and penicillins. 

Acute tubular necrosis (exogenous toxins) Aminoglycosides, amphotericin, cisplatin, radiocontrast agents, methoxyflurane, outdated tetracyclines, cephalosporins, mithramycin, calcineurin inhibitors, pentamidine, IVIG, ifosfamide, zoledronate, cidofovir, adefovir, tenofovir FENa>2%, UOsm <350, urinary sediment contains granular casts, renal epithelial cells... 

Clinically important, potentially hazardous interactions with aminoglycosides, clindamycin, cyclopropane, enflurane, halothane, isoflurane, methoxyflurane, piperacillin, rocuronium... 

Clinically important, potentially hazardous interactions with adefovir, aldesleukin, aminoglycosides, atracurium, bumetanide, carbenicillin, cephalexin, cephalothin, doxacurium, ethacrynic acid, furosemide, methoxyflurane, non-polarizing muscle relaxants, pancuronium, pipecuronium, polypeptide antibiotics, rocuronium, succinylcholine, teicoplanin, torsemide, tubocurarine, vecuronium... 

Drugs with nephrotoxic potential include ACE inhibitors, acetazolamide. aminoglycosides, aspirin, amphotericin B, cyclosporine, furosemide, gold salts, lithium, methicillin, methoxyflurane, NSAIDs, pentamidine, sulfonamides, tetracyclines (degraded), thiazides, and triamterene. 

The nephrotoxic effects of methoxyflurane appear to be increased by the use of tetracyciines, and possibiy some aminoglycoside an-tibacteriais and barbiturates. 

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