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Methods/test procedures analytical methodology

There is a discrepancy between the cyanide criteria for both aquatic and drinking water standards and the current analytical technology. The criteria are stated for free cyanide (which Includes hydrocyanic acid and the cyanide ion), but the EPA approved analytical methodology for total cyanide measures the free and combined forms (11). This test probably overestimates the potential toxicity. An alternative method (cyanides amenable to chlorination) measures those cyanide complexes which are readily dissociated, but does not measure the iron cyanide complexes which dissociate in sunlight. This method probably tends to underestimate the potential toxicity. Other methods have been proposed, but similar problems exist (12). The Department of Ecology used the EPA-approved APHA procedure which includes a distillation step for the quantification of total cyanide (13,14). A modification of the procedure which omits the distillation step was used for estimation of free cyanide. Later in the study, the Company used a microdiffusion method for free cyanide (15). [Pg.23]

HPLC is a complex analytical methodology that involves the development of a unique method for each new application. This method development often requires the optimisation of several method conditions to achieve a desired selectivity and sensitivity [12,13]. HPLC is also one of the most commonly applied analytical techniques and is in widespread use throughout the pharmaceutical industry for applications as diverse as quality control, stability studies and clinical trials. These two reasons mean that HPLC has been the focus of most research into ruggedness testing procedures because it is most likely to require extensive ruggedness... [Pg.198]

The process for the transfer of analytical methodology is, on the surface, a relatively simple operation. In its most common form, analytical method transfer is the verification that a method or test procedure works in an equivalent fashion at two or more different sites or laboratories and meets all acceptance criteria. This process is driven by compliance and governed by a statistical treatment of the resulting data. This interlaboratory transfer aspect of the overall transfer process has been covered comprehensively by McGonigle, who stressed that successful transfers are linked to the method validation process. Method transfer was defined in this case as the introduction of a validated method into a designated laboratory so that it can be used in the same capacity for which it was originally developed. The second portion of the technology transfer... [Pg.485]

The process for the transfer of analytical methodology is, on the surface, a relatively simple operation. In its most common form, analytical method transfer is the verification that a method or test procedure works in an equivalent fashion... [Pg.507]

The results have shown that we have developed a sensitive and specific ELISA assay for the analysis of clomazone residues from soil samples. The procedures have demonstrated good recovery of clomazone from soil, and excellent correlation of the ELISA test results with standard GLC methodology. In addition, the results of the ELISA tests demonstrate good correlation between the observed soil levels of clomazone, and crop injury when the bioassay is performed under controlled, greenhouse conditions. This assay could, therefore, be used as a more rapid and convenient analytical method over the standard GLC technique after further validation. [Pg.178]

With this approach, we describe applicability of each method, including capabilities and limitations. Most workers in catalyst development are not necessarily expert in analytical procedures. The techniques described are usually available within the facilities of most companies or from outside testing laboratories. For this reason, details of instrumentation and methodology have been minimized in order to concentrate on what should... [Pg.137]

In contrast to the ultraviolet and visible absorption methods described earlier, details of the methodology of luminescence spectroscopy are not widely known and few standard methods have evolved. Books on theory and techniques are helpful (44) as are memoranda on applications from instrument manufacturers. ASTM Committee E-13.06 on Molecular Luminescence has had large task forces working for several years on practices for instrument testing, nomenclature, and analytical procedures. Recent symposia sponsored by that committee are the basis for two new books (45, 6). [Pg.708]

It has been stated to be the most specific spectroscopic method available for phosphate analysis and was therefore widely used and dealt with in published literature. Since details in the test conditions described vary somewhat in-between the methods published, it is evident that the procedure has some inherent ruggedness. This applies especially when the methodology is used for identification purposes only, not measuring the absorbance at a specific wavelength and not comparing with a standard. In literature dealing with the method used for assays, the reagent and analyt concentrations vary in intervals stated below. [Pg.70]


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