Methodology application

Gunsteren W F and H J C Berendsen 1990. Computer Simulation of Molecular Dynamics Methodology, Applications and Perspectives in Chemistry. Angewandte Chemie International Edition in English 29 992-1023. 

The appearance of the 2-(indol-3yl)ethylamine (tryptamine) unit in both tryptophan-derived natural products and in synthetic materials having potential pharmacological activity has generated a great deal of interest in the synthesis of such compounds. Several procedures which involve either direct 3-alkylation or tandem 3-functionalization/modification have been developed. Similarly, methodology applicable to preparation of tryptophan analogues has been widely explored. 

See van Gunsteren, W.F. Berendsen, H.J.C. Computer simulation of molecular dynamics-methodology, applications, and perspectives in chemistry Angewandre Chemie, International Edition in English, 29 992-1023, 1990, and Karplus, M. Petsko, G.A. Molecular dynamics simulations in biology Nature 347 631-639, 1990. 

RSSMAP - Reactor Safety Study Methodology Applications Program. 

Boyd, G.J., et al., Final Report Phase 1 Systems Interaction Methodology Applications Program, April 1980... 

Task analysis is a fundamental methodology in the assessment and reduction of human error. A very wide variety of different task analysis methods exist, and it would be impracticable to describe all these techniques in this chapter. Instead, the intention is to describe representative methodologies applicable to different types of task. Techniques that have actually been applied in the CPI will be emphasized. An extended review of task analysis techniques is available in Kirwan and Ainsworth (1993). 

More general methodology applicable to a wider variety of complex rules is introduced in chapters 4 and 5. 

Van Gunsteren WF Berendsen HJC. Computer simulation of molecular dynamics methodology, application and perspectives in chemistry. Angew. Chem. Int. Ed. Eng. 1990 29 992-996. 

Padron Sanz, C., Z. Sosa Ferrera, and J.J. Santana Rodriguez. 2002. Extraction and preconcentration of polychlorinated dibenzo-p-dioxins using the cloud-point methodology. Application to their determination in water samples by high-performance liquid chromatography. Anal. Chim. Acta 470 205-214. 

V Snieckus, The Directed Ortho Metalation Reaction. Methodology, Applications, Synthetic Links, and a Nonaromatic RamificationP PureAppl. Chem. 1990, 62, 2047-2056. 

To develop a methodology applicable to the design of a wide range of multinuclear active sites on the backbones of insoluble polymers we prepared a molecular entity, composed of various catalytic elements, with a precisely defined structure and then attached it to a polymeric backbone. Thus, we synthesized catalytic modules containing one, two, or four metal-chelating sites, which were subsequently attached to a polystyrene derivative to produce 21-23 [55]. 

This chapter deals with electrode reactions in microvolumes, which we define as volumes of solution of 100 p.L or less, either total volume or microvolume contained within a larger quantity of solution. Particular attention will be paid to the strategies used to obtain experimental results under such conditions. The theoretical analysis of the results leading to the relevant thermodynamic, kinetic and mechanistic parameters can often follow the methodologies applicable for electrode reactions in larger solution volumes such treatments are available elsewhere, e.g., [1]. Emphasis... 

Coutinho, K. and Canuto S., The sequential Monte Carlo-quantum mechanics methodology. Application to the solvent effects in the Stokes shift of acetone in water. J. Mol.Struct. (THEOCHEM) ... 

Table 4.1 Exemplary similarity-based methodologies applicable to virtual screening. ... 

F. F. Abraham, Adv. Phys., 35, 1,1986. Computational Statistical Mechanics Methodology, Applications and Supercomputing. 

Computer Simulation of Molecular Dynamics Methodology, Applications, and Perspectives in Chemistry. 

The above processes constitute the foundation on which Wenkert developed a general synthetic methodology applicable to terpenoid and alkaloid syntheses. In some instances, the carbonyl can be viewed as a vinyl moiety participating in the overall heterovinylcyclopropane-cyclopentene rearrangement, as shown in Scheme 45, even though the mechanism involves the cyclopropylcarbinyl rearrangement. Some applications of this reaction are shown in Table 8. 

Comparison of the MO and VB approaches Developments in VB methodology Applications of VB theory Concluding remarks... 

Verification of the Methodology Application to a Simulated Load-Time Curve... 

Fault seal analysis successful methodologies, application and future directions... 

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