Methantheline

Methanol, l-isoquinolyl(phenyl)-confonnation, 2, 110 Methanol, pyrimidinyl-synthesis, 3, 113 Methanol, tetrahydropyran-2-yl-microwave spectra, 3, 625 Methantheline as neurotransmitter, 1, 175 therapeutic properties, 3, 882 Methaphenilene biological activity, 4, 911 Methapyrilene biological activity, 4, 911 toxicity, 4, 912 Methaqualone, 3, 150 as anticonvulsant, 1, 166 pyrido[2,3-d]pyrimidine analogues metabolism, 3, 205 as sedative, 1, 166 Metharbitone as anticonvulsant, 1, 166 Methazolamide... 

A great many organic quaternary bases can inhibit the action of acetyl choline in organ systems activated by that neurotransmitter and thus possess anticholinergic-antispasmodic activity. One such agent is methantheline bromide (4), used in the treatment of peptic ulcer and as an antispasmodic agent in intestinal disorders. Its synthesis Involves Friedel-Crafts cyclization of o-... 

Mepyramine (pyrilamine) Methanthelinium bromide (methantheline bromide) Metharbitone (metharbital) Methylergometrine (methylergonovine) Methohexitone (methohexital)... 

Methantheline and propantheline are synthetic derivatives that, besides their antimuscarinic effects, are ganglionic blocking agents and block the skeletal neuromuscular junction. Propantheline and oxyphenonium reduce gastric secretion, whereas pirenzepine, in addition to reducing gastric secretion, also reduces gastric motility. 

Propantheline bromide (Pro-banthine) resembles methantheline chemically (isopropyl groups replace the ethyl substituents on the quaternary N atom). Its pharmacological properties are also similar to those of methantheline, but it is two to five times more potent. It is one of the more widely used of the synthetic muscarinic receptor antagonists. Very high doses block the skeletal neuromuscular junction. The usual clinical dose (15 mg) acts for about 6 h. 

Methantheline and propantheline are synthetic derivatives that, in addition to their antimus-... 

Anionic micellar systems were found to increase the rate of the acid catalyzed hydrolysis of acetylsalicylic acid (Nogami et al., 1962), methantheline bromide (Nogami and Awazu, 1962), n-butyl acetate, t-butyl acetate, ethyl p-aminobenzoate, and ethyl o-aminobenzoate (Sakurada et al., 1967), but decreased that of methyl benzoate slightly (Sakurada et al., 1967). The acid catalyzed hydrolysis of anionic amphi-philes also generally tend to be accelerated by micellization (Table 5). The rates of the acid catalyzed hydrolyses of sodium sulfoethyl do-decanoate, sodium undecanoate, and sodium sulfobutyl caprylate are significantly greater in micellar than in non-micellar solutions while that of sodium dodecyl sulfoacetate is unaffected by micelle formation (Meguro and Hikota, 1968). 

Synonyms. Bromuro de Metantelina Dixamonum Bromidum Methantheline Bromide Methanthine Bromide. 

---