Metal-NO complex

As well as NONOates, other NO donors also showed anticancer activity independently. Sodium nitroprusside (SNP), a metal-NO complex, showed cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma [109]. SNP and cytosine arabinoside (Ara-C) did not share the drug resistance. Interestingly, SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP has an anti-tumor effect on human hematological malignant cells. 

Metal-NO complexes Structures, Syntheses, Properties and NO-releasing Mechanisms... 

Nitric oxide (NO) has profound biological significance and was named Molecule of the Year by Science magazine in 1992 (157). This also has resulted in the appearance of an increasing number of experimental and theoretical studies on metal-NO complexes (158-161). 

Ghosh A, Hopmann KH, Conradie J (2009) Electronic structure calculations transition Metal-NO complexes. In Solomon El, King RB, Scott RA (eds) Computational inorganic and bioinorganic chemistry. Wiley, Chichester... 

Flayton TW, Legzdins P, Sharp WB (2002) Coordination and organometallic chemistry of metal-NO complexes. Chem Rev 102 935-992... 

The simplest example of a reference level consists in the Fermi level of a metal in a metal/metal junction it is the Fermi energies that align. Thus, in order to determine the discontinuities between the bands of the two metals, one merely needs to know the energy levels relative to Ef, which is taken as the reference level [ p = r(metal)] no complex numerical calculations are necessary at the interface. 

The chemistry of transition metal NO complexes has been extensively reviewed. " ... 

NO donors may play some role as novel cancer therapeutics when used alone or with existing cancer chemotherapy agents (Huerta et al. 2008). NO donors available or in development include organic nitrates, metal-NO complexes, 5-nitrosothiols, sydnonimines (which produce both NO and superoxide, and hence peroxynitrite), diazeniumdiolates ( NONOates ), and certain NO-hybrids (NO linked to active drugs of other classes) (Huerta et al. 2008). Examples of NO-hybrids include NO-aspirin, other NO-nonsteroidal anti-inflammatory drugs, and NO-statins. 

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