Metabolomics/metabonomics

Metabolomics, Metabonomics and Metabolite Profiling 10 Ribozymes and RNA Catalysis 11 Protein-Nucleic Acid Interactions Structural Biology 12 Therapeutic Oligonucleotides... 

FIGURE 2 Plot of the number of publications on the field of metabolomics/metabonomics and the following analytical technologies (1) mass spectrometry (blue diamond), (2) chromatography (green triangle), and (3) NMR spectroscopy (red box). Based on search in Scopus. 

Metabolomics/Metabonomics is the application of systems-wide techniques (normally based on NMR) for metabolic profiling. Some scientists use the term metabolomics to describe such analyses in both simple (cellular) and complex (tissue or whole body) systems. Others distinguish between metabolomics studies in simple systems only (e.g., cell culture) and metabonomics studies performed in complex systems (e.g., the human body). 

Wang, Y. and Griffiths, W. J. 2008. Mass Spectrometry for Metabolite Identification, in Metabolomics, Metabonomics and Metabolite Profiling, ed. W. J. Griffiths, 1-43. Gambridge Royal Society of Chemistry. 

Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc. 2007 2 2692-2703. 

Metabolism is considered to be a phenotype. It integrates all the factors from nutrition to environment to genetics assessing one s current state of health. Metabolomics arose from metabolic control theory and was originally based on the metabolome, which is defined as the metabolic composition of a cell and is analogous to the genome or proteome. In metabonomics, static cellular and biofluid concentrations of endogenous metabolites are evaluated over a time-course. 

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