Metabolic control theory

Hafher, R.P., Brown, G.C.. Brand, M.D. (1990). Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and proton motive force in isolated mitochondria using the top-down approach of metabolic control theory. Eur. J. Biochem. 188,313-319. 

C. Reder, Metabolic control theory A structural approach. J. Theoret. Biol. 135, 175 201 (1988). 

M. A. Savageau, Biochemical systems theory and metabolic control theory 1. Fundamental similarities and differences. Math. Biosci. 86, 127 145 (1987). 

Reder, C. Metabolic control theory a structural approach. J Theor Biol 1988, 135 175-201. 

Kahn, D. and Westerhoff, H.V. (1993) Regulation and homeostasis in metabolic control theory interplay between fluctuations of variables and parameter changes. In Modem Trends in BioThermoKinetics. S. Schuster, M. Rigoulet, R. Ouhabi, J.P. Mazat, ed. (New York Plenum Press), pp. 199-204. 

Kholodenko, B.N., Demin, O.V and Westerhoff, H.V. (1996) The metabolic control theory of biochemical oscillating systems. 1. Definitions of the quantitative characteristics and their simplest properties. Biochemistry Mosc. 61, 423 34. 

Metabolism is considered to be a phenotype. It integrates all the factors from nutrition to environment to genetics assessing one s current state of health. Metabolomics arose from metabolic control theory and was originally based on the metabolome, which is defined as the metabolic composition of a cell and is analogous to the genome or proteome. In metabonomics, static cellular and biofluid concentrations of endogenous metabolites are evaluated over a time-course. 

Sen, A. K. 1990. Metabolic control theory A graph theoretic approach. Biomed Biochim Acta 48 817-27. 

Savageau M A, Voit E O and Irvine D H 1987 Biochemioal systems theory and metabolic control theory 2. The role of summation and connectivity relationships Math. Biosci. 86 147-69... 

The object of metabolic control theory is to provide a sound mathematical foundation for the quantitative estimation of the role played by individual enzymes on the control of flux through a metabolic pathway and also the control exerted by individual enzymes on the concentration of intermediate metabolites in the pathway. The general principles of metabolic control theory and biochemical systems theory can be visualized by considering the simple metabolic pathway in Fig. 6. The numbers above the arrows... 

MetaboUc flux analysis has not yet been applied to this system. It has been suggested that an extension of the principles of metabolic control theory would make it possible to identify rational optimal strategies for improvement of ergot alkaloid formation [4]. 

According to others studies on mammalian mitochondria, in both species of Phaseolus there is not concordance with the summation theorem of the Metabolic Control Theory. 

Reder C (1988) Metabolic control theory a structural approach. J Theor Biol 135 175-201 Reed JL, Palsson B0 (2004) Genome-scale in silico models of E. coli have multiple equivalent phenotypic states assessment of correlated reaction subsets that comprise network states. Genome Res 14 1797-1805... 

Those of us that have done basic research have tended to look at enzyme activity, pathway activity, hormone and receptor concentrations and the like. That is fine, and we have learned from that, but in many oases we did not consider the underlying controls (transcription rates, enzyme synthesis rates) or did not fully relate the cellular information to the animal production level in any systematic mathematical formalism. The former is difficult to do, expensive, and in many ways not necessary to our purposes in animal agriculture. The latter is easy to do, inexpensive and in fact an absolute requirement for our purposes what are the true biological controls, at the level at which control is exerted, that drive animal production. A description of metabolic control theory and control coefficients is beyond the purpose of this article, but readers are at least encouraged to read some of Kacser, Carson and Cobelli and Comish-Bowden to understand this (Comish-Bowden, 2005). I will go into more detail with references on multiple regressions to study the relationship of basic metabolic control, transcriptomics and animal production below. 

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